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    Itgb4 integrin beta 4 [ Mus musculus (house mouse) ]

    Gene ID: 192897, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itgb4provided by MGI
    Official Full Name
    integrin beta 4provided by MGI
    Primary source
    MGI:MGI:96613
    See related
    Ensembl:ENSMUSG00000020758 AllianceGenome:MGI:96613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD104; C230078O20
    Summary
    Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in colon adult (RPKM 42.1), small intestine adult (RPKM 34.8) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Itgb4 in Genome Data Viewer
    Location:
    11 E2; 11 80.91 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115865556..115899238)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115974725..116008412)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RecQ protein-like 5 Neighboring gene small integral membrane protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E1850 Neighboring gene STARR-seq mESC enhancer starr_31180 Neighboring gene STARR-seq mESC enhancer starr_31181 Neighboring gene SAP30 binding protein Neighboring gene predicted gene, 39474 Neighboring gene STARR-seq mESC enhancer starr_31187 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115873522-115873709 Neighboring gene galactokinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E306 Neighboring gene STARR-seq mESC enhancer starr_31191 Neighboring gene H3.3 histone B Neighboring gene predicted gene, 38482 Neighboring gene unkempt family zinc finger

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to insulin-like growth factor I binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to neuregulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to neuregulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hemidesmosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hemidesmosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myelination in peripheral nervous system IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nail development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nail development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peripheral nervous system myelin formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to wounding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in skin morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skin morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within trophoblast cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in hemidesmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in hemidesmosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005608.3NP_001005608.2  integrin beta-4 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL607108, AL645647
      Consensus CDS
      CCDS36376.1
      UniProtKB/TrEMBL
      A2A864
      Related
      ENSMUSP00000127604.2, ENSMUST00000169928.8
      Conserved Domains (7) summary
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15081589
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:545575
      EGF_2; EGF-like domain
      pfam00041
      Location:16221707
      fn3; Fibronectin type III domain
      pfam07965
      Location:628710
      Integrin_B_tail; Integrin beta tail domain
      pfam18372
      Location:459487
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    2. NM_001405126.1NP_001392055.1  integrin beta-4 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL607108, AL645647
      Related
      ENSMUSP00000070811.7, ENSMUST00000068981.13
    3. NM_001405127.1NP_001392056.1  integrin beta-4 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL607108, AL645647
    4. NM_133663.3NP_598424.2  integrin beta-4 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL607108, AL645647
      Conserved Domains (7) summary
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:14581539
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:547575
      EGF_2; EGF-like domain
      pfam00041
      Location:15721657
      fn3; Fibronectin type III domain
      pfam07965
      Location:628710
      Integrin_B_tail; Integrin beta tail domain
      pfam18372
      Location:459487
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115865556..115899238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156446.1XP_036012339.1  integrin beta-4 isoform X8

      Conserved Domains (6) summary
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:14551536
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:15691654
      fn3; Fibronectin type III domain
      pfam07965
      Location:628710
      Integrin_B_tail; Integrin beta tail domain
      pfam18372
      Location:459487
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    2. XM_017314349.3XP_017169838.1  integrin beta-4 isoform X1

      Conserved Domains (7) summary
      smart00237
      Location:9921086
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15771658
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:545575
      EGF_2; EGF-like domain
      pfam00041
      Location:16911776
      fn3; Fibronectin type III domain
      pfam07965
      Location:628711
      Integrin_B_tail; Integrin beta tail domain
      pfam18372
      Location:459487
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    3. XM_006532572.5XP_006532635.1  integrin beta-4 isoform X4

      See identical proteins and their annotated locations for XP_006532635.1

      UniProtKB/Swiss-Prot
      A2A863, A2A865, A2A866, Q6PCS0, Q8R3J1, Q91W15
      Related
      ENSMUSP00000102069.2, ENSMUST00000106461.8
      Conserved Domains (7) summary
      smart00237
      Location:9921086
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15241605
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:545575
      EGF_2; EGF-like domain
      pfam00041
      Location:16381723
      fn3; Fibronectin type III domain
      pfam07965
      Location:628711
      Integrin_B_tail; Integrin beta tail domain
      pfam18372
      Location:459487
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    4. XM_006532573.5XP_006532636.1  integrin beta-4 isoform X5

      UniProtKB/Swiss-Prot
      A2A863
      Related
      ENSMUSP00000102068.3, ENSMUST00000106460.9
      Conserved Domains (7) summary
      smart00237
      Location:9921086
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15121593
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:545575
      EGF_2; EGF-like domain
      pfam00041
      Location:16261711
      fn3; Fibronectin type III domain
      pfam07965
      Location:628711
      Integrin_B_tail; Integrin beta tail domain
      pfam18372
      Location:459487
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    5. XM_017314351.3XP_017169840.1  integrin beta-4 isoform X3

      Conserved Domains (7) summary
      smart00237
      Location:9921086
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15741655
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:545575
      EGF_2; EGF-like domain
      pfam00041
      Location:16881773
      fn3; Fibronectin type III domain
      pfam07965
      Location:628711
      Integrin_B_tail; Integrin beta tail domain
      pfam18372
      Location:459487
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    6. XM_017314350.3XP_017169839.1  integrin beta-4 isoform X2

      Conserved Domains (7) summary
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15761657
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:545575
      EGF_2; EGF-like domain
      pfam00041
      Location:16901775
      fn3; Fibronectin type III domain
      pfam07965
      Location:628710
      Integrin_B_tail; Integrin beta tail domain
      pfam18372
      Location:459487
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    7. XM_036156447.1XP_036012340.1  integrin beta-4 isoform X9

      UniProtKB/TrEMBL
      Q3UNP2
      Conserved Domains (3) summary
      smart00237
      Location:94188
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:679760
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:793878
      fn3; Fibronectin type III domain