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    Fst follistatin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24373, updated on 9-Dec-2024

    Summary

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    Symbol
    Fstprovided by RGD
    Full Name
    follistatinprovided by RGD
    Primary source
    RGD:2633
    See related
    EnsemblRapid:ENSRNOG00000011631 AllianceGenome:RGD:2633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FS; FOL1; Fst-288; RATFOL1
    Summary
    Enables heparan sulfate proteoglycan binding activity. Involved in cellular response to growth factor stimulus and response to organic cyclic compound. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 36.4), Muscle (RPKM 32.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fst in Genome Data Viewer
    Location:
    2q14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (47856345..47863670, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (46123260..46130584, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (46537589..46544813, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 15 Neighboring gene uncharacterized LOC120100716 Neighboring gene transfer RNA threonine (anticodon AGU) 8 Neighboring gene NADH:ubiquinone oxidoreductase subunit S4 Neighboring gene uncharacterized LOC120100717 Neighboring gene uncharacterized LOC103691459 Neighboring gene developmental pluripotency-associated protein 4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Follistatin expression in the central nervous system of the adult rat. Ogawa C, et al. J Chem Neuroanat, 2020 Apr. PMID 32014555
    2. Follistatin gene expression in the ovary and extragonadal tissues. Shimasaki S, et al. Mol Endocrinol, 1989 Apr. PMID 2725528
    3. Structural and functional characterization of the rat follistatin (activin-binding protein) gene promoter. Miyanaga K, et al. Mol Cell Endocrinol, 1993 Mar. PMID 8472873
    4. Dynamics of messenger RNAs encoding inhibin/activin subunits and follistatin in the ovary during the rat estrous cycle. Arai KY, et al. Biol Reprod, 2002 Apr. PMID 11906933
    5. Evidence that PACAP and GnRH down-regulate follicle-stimulating hormone-beta mRNA levels by stimulating follistatin gene expression: effects on folliculostellate cells, gonadotrophs and LbetaT2 gonadotroph cells. Fujii Y, et al. Mol Cell Endocrinol, 2002 Jun 28. PMID 12088867

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage.
      Title: Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage.
    2. Follistatin expression in the central nervous system of the adult rat.
      Title: Follistatin expression in the central nervous system of the adult rat.
    3. These data suggest that ghrelin inhibits myocardial fibrosis, attenuates left ventricular remodeling, and eventually improves cardiac function by adjusting Act A/FS imbalance.
      Title: Ghrelin suppresses cardiac fibrosis of post-myocardial infarction heart failure rats by adjusting the activin A-follistatin imbalance.
    4. manifestation of polycystic ovarian syndrome-like phenotype following prenatal exposure to excess androgen is associated with irregularity in expression of the FST gene during the estrus cycle
      Title: Alteration in follistatin gene expression detected in prenatally androgenized rats.
    5. Results show that Myostatin and follistatin protein expression is reduced in the long-term hypertrophied myocardium from spontaneously hypertensive rats with heart failure.
      Title: Myocardial myostatin in spontaneously hypertensive rats with heart failure.
    6. Myogenin, myostatin, and follistatin expression is lower and myogenic regulatory factor (MRF)4 levels higher in spontaneously hypertensive rats (SHR) with heart failure compared to the Wistar-Kyoto strain.
      Title: Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.
    7. Expression of follistatin and myostatin mRNA is increased in muscle and subcutaneous fat of sedentary diabetic rats compared with sedentary control rats.
      Title: Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise.
    8. The ratio of follistatin/myostatin could be used to monitor the progress of target muscle atrophy and recovery.
      Title: A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood.
    9. Fst expression is necessary for the proliferation of small hepatocytes.
      Title: Proliferation of rat small hepatocytes requires follistatin expression.
    10. Effects of training and androgens on MYOPRO and FOLLI concentrations in blood and skeletal muscle, were investigated.
      Title: Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle using highly sensitive immuno PCR.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables activin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables activin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables activin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables activin receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparan sulfate proteoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of ameloblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within female gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hair follicle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of follicle-stimulating hormone secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pattern specification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    follistatin
    Names
    activin-binding protein
    follistatin-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012561.4 → NP_036693.1  follistatin precursor

      See identical proteins and their annotated locations for NP_036693.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P21674, Q80XW7
      Related
      ENSRNOP00000015680.1, ENSRNOT00000015680.6
      Conserved Domains (2) summary
      smart00274
      Location:94 → 117
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:117 → 164
      KAZAL; Kazal type serine protease inhibitors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      47856345..47863670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231953.5 → XP_006232015.1  follistatin isoform X1

      Conserved Domains (2) summary
      smart00274
      Location:94 → 117
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:117 → 164
      KAZAL; Kazal type serine protease inhibitors

    2. XM_006231954.5 → XP_006232016.1  follistatin isoform X2

      Conserved Domains (2) summary
      smart00274
      Location:94 → 117
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:117 → 164
      KAZAL; Kazal type serine protease inhibitors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21674.1 GenPept UniProtKB/Swiss-Prot:P21674

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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