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    pnp-1 Purine nucleoside phosphorylase [ Caenorhabditis elegans ]

    Gene ID: 176851, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pnp-1
    Official Full Name
    Purine nucleoside phosphorylase
    Primary source
    WormBase:WBGene00019298
    Locus tag
    CELE_K02D7.1
    See related
    AllianceGenome:WB:WBGene00019298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable purine-nucleoside phosphorylase activity. Involved in innate immune response. Predicted to be active in cytoplasm. Is expressed in epithelial cell; head neurons; and intestine. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pnp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (292433..298280, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene Sugar transporter SWEET1 Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity. Martell J, et al. Cell Chem Biol, 2016 Aug 18. PMID 27499530, Free PMC Article
    2. Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes. Venzon M, et al. Cell Host Microbe, 2022 Jun 8. PMID 35413267, Free PMC Article
    3. Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection. Olaitan AO, et al. PLoS Genet, 2018 Sep. PMID 30265660, Free PMC Article
    4. The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans. Tecle E, et al. PLoS Pathog, 2021 Apr. PMID 33878133, Free PMC Article
    5. The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans. Lažetić V, et al. Nat Commun, 2022 Jan 10. PMID 35013162, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine-nucleoside phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-nucleoside phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Purine nucleoside phosphorylase
    NP_001368342.1
    • Confirmed by transcript evidence
    NP_001379888.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      292433..298280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392243.1 → NP_001379888.1  Purine nucleoside phosphorylase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61217
      Conserved Domains (1) summary
      TIGR01700
      Location:44 → 297
      PNPH; purine nucleoside phosphorylase I, inosine and guanosine-specific

    2. NM_001380002.1 → NP_001368342.1  Purine nucleoside phosphorylase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PSA1
      Conserved Domains (1) summary
      TIGR01700
      Location:61 → 314
      PNPH; purine nucleoside phosphorylase I, inosine and guanosine-specific
    Nucleotide Protein
    Heading Accession and Version

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