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    Preb prolactin regulatory element binding [ Mus musculus (house mouse) ]

    Gene ID: 50907, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prebprovided by MGI
    Official Full Name
    prolactin regulatory element bindingprovided by MGI
    Primary source
    MGI:MGI:1355326
    See related
    Ensembl:ENSMUSG00000045302 AllianceGenome:MGI:1355326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mSec12
    Summary
    Enables GTPase binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in COPII vesicle coating; positive regulation of transcription by RNA polymerase II; and regulation of COPII vesicle coating. Predicted to be located in nucleus. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; jaw; metanephros; and surface ectoderm. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 35.0), large intestine adult (RPKM 34.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Preb in Genome Data Viewer
    Location:
    5 B1; 5 16.9 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31109011..31117700, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30951667..30960356, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4749 Neighboring gene ketohexokinase Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E1679 Neighboring gene abhydrolase domain containing 1 Neighboring gene transcription factor 23 Neighboring gene STARR-seq mESC enhancer starr_12765 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E2741 Neighboring gene all-trans retinoic acid induced differentiation factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in COPII vesicle coating ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in COPII vesicle coating ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of COPII vesicle coating IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of COPII vesicle coating IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of COPII vesicle coating ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum exit site ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-exchange factor SEC12; prolactin regulatory element-binding protein
    Names
    mammalian guanine nucleotide exchange factor Sec12
    mammalian guanine nucleotide exchange factor mSec12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001294302.1NP_001281231.1  guanine nucleotide-exchange factor SEC12 isoform 2

      See identical proteins and their annotated locations for NP_001281231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK013330, AK029838, AK151288, BP765513, CJ145010
      Consensus CDS
      CCDS80244.1
      UniProtKB/TrEMBL
      D3Z3S1
      Related
      ENSMUSP00000144263.2, ENSMUST00000202567.2
      Conserved Domains (3) summary
      COG2319
      Location:140327
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:160194
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:159327
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001422185.1NP_001409114.1  guanine nucleotide-exchange factor SEC12 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109606
    3. NM_016703.3NP_057912.2  guanine nucleotide-exchange factor SEC12 isoform 1

      See identical proteins and their annotated locations for NP_057912.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encode the longer isoform (1).
      Source sequence(s)
      AK013330, AK029838, AK151288, BP765513, CJ145010
      Consensus CDS
      CCDS39051.1
      UniProtKB/Swiss-Prot
      Q9QZ99, Q9WUQ2
      UniProtKB/TrEMBL
      Q3UAP1
      Related
      ENSMUSP00000074387.6, ENSMUST00000074840.12
      Conserved Domains (2) summary
      sd00039
      Location:160194
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:159353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_185490.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109606
    2. NR_185491.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109606

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31109011..31117700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504015.2XP_006504078.1  prolactin regulatory element-binding protein isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:153193
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:159231
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_036165264.1XP_036021157.1  prolactin regulatory element-binding protein isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:153193
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:159231
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006504017.4XP_006504080.1  prolactin regulatory element-binding protein isoform X4

      Conserved Domains (2) summary
      sd00039
      Location:153193
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:159231
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_004942534.1 RNA Sequence

    2. XR_004942536.1 RNA Sequence