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    Lonp2 lon peptidase 2, peroxisomal [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291922, updated on 27-Nov-2024

    Summary

    Official Symbol
    Lonp2provided by RGD
    Official Full Name
    lon peptidase 2, peroxisomalprovided by RGD
    Primary source
    RGD:1305466
    See related
    EnsemblRapid:ENSRNOG00000015162 AllianceGenome:RGD:1305466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00016; RGD1305466
    Summary
    Predicted to enable peptidase activity and protease binding activity. Involved in response to organic cyclic compound. Located in peroxisomal matrix. Orthologous to human LONP2 (lon peptidase 2, peroxisomal). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 999.5), Kidney (RPKM 539.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lonp2 in Genome Data Viewer
    Location:
    19p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (36580736..36672242, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (20407475..20498985, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (21400736..21492634, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547741 Neighboring gene siah E3 ubiquitin protein ligase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene ATP binding cassette subfamily C member 12 Neighboring gene uncharacterized LOC134483622

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into peroxisome matrix IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein quality control for misfolded or incompletely synthesized proteins IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein targeting to peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein targeting to peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisomal matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lon protease homolog 2, peroxisomal
    Names
    lon protease 2
    lon protease-like protein 2
    peroxisomal Lon protease homolog 2
    NP_001386125.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399196.1NP_001386125.1  lon protease homolog 2, peroxisomal

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q3MIB4
      UniProtKB/TrEMBL
      B2GUU4
      Related
      ENSRNOP00000020770.4, ENSRNOT00000020770.9
      Conserved Domains (1) summary
      COG0466
      Location:11838
      Lon; ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      36580736..36672242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033689.1: Suppressed sequence

      Description
      NM_001033689.1: This RefSeq was removed because currently there is insufficient support for the transcript.