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    Cav2 caveolin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363425, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cav2provided by RGD
    Official Full Name
    caveolin 2provided by RGD
    Primary source
    RGD:620348
    See related
    AllianceGenome:RGD:620348
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables mitogen-activated protein kinase kinase kinase binding activity; phosphoprotein binding activity; and syntaxin binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of endothelial cell proliferation; and positive regulation of peptidyl-tyrosine phosphorylation. Located in several cellular components, including caveola; lipid droplet; and nuclear inner membrane. Part of protein-containing complex. Biomarker of high grade glioma and obesity. Human ortholog(s) of this gene implicated in low tension glaucoma and primary open angle glaucoma. Orthologous to human CAV2 (caveolin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 1125.0), Heart (RPKM 413.6) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cav2 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (46582681..46590058)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (45616766..45624144)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (44573264..44580640)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene testin LIM domain protein Neighboring gene uncharacterized LOC102550644 Neighboring gene caveolin 1 Neighboring gene uncharacterized LOC103692063

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC72322

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D1 dopamine receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in basement membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within basement membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in caveola assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in caveola assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in caveola assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in caveola assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endoplasmic reticulum organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of skeletal muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of skeletal muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation by host of viral process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dopamine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor-mediated endocytosis of virus by host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis of virus by host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of skeletal muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle fiber development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle docking IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle docking ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle docking ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in vesicle fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in vesicle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral release from host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of caveolar macromolecular signaling complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of caveolar macromolecular signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131914.3NP_571989.3  caveolin-2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q2IBC5, Q6P6R8, Q8VIK7
      UniProtKB/TrEMBL
      A0A0A0MXU8, A6IE19
      Conserved Domains (1) summary
      pfam01146
      Location:39160
      Caveolin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      46582681..46590058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)