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    Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 56292, updated on 27-Nov-2024

    Summary

    Official Symbol
    Naa10provided by MGI
    Official Full Name
    N(alpha)-acetyltransferase 10, NatA catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1915255
    See related
    Ensembl:ENSMUSG00000031388 AllianceGenome:MGI:1915255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Te2; Ard1; Ard1a; 2310039H09Rik
    Summary
    Enables N-acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation and negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; heart; liver; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Orthologous to human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 30.5), large intestine adult (RPKM 29.1) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Naa10 in Genome Data Viewer
    Location:
    X A7.3; X 37.49 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72960476..72965550, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73916870..73921944, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene L1 cell adhesion molecule Neighboring gene Rho GTPase activating protein 4 Neighboring gene arginine vasopressin receptor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:71157031-71157252 Neighboring gene STARR-seq mESC enhancer starr_47360 Neighboring gene renin binding protein Neighboring gene STARR-seq mESC enhancer starr_47361 Neighboring gene host cell factor C1 Neighboring gene STARR-seq mESC enhancer starr_47362

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide alpha-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptide-alanine-alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide-glutamate-alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide-serine-alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide-serine-alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NatA complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of NatA complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    N-alpha-acetyltransferase 10
    Names
    ARD1 homolog A, N-acetyltransferase
    N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha acetyltransferase 10
    N-terminal acetyltransferase complex ARD1 subunit homolog A
    Nalpha acetyltransferase 10
    alpha-N-acetyltransferase 1A
    natA catalytic subunit Naa10
    NP_001171436.1
    NP_001297467.1
    NP_063923.1
    XP_036017930.1
    XP_036017931.1
    XP_036017932.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177965.1NP_001171436.1  N-alpha-acetyltransferase 10 isoform 2

      See identical proteins and their annotated locations for NP_001171436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK003806, AL672002, BY101790
      Consensus CDS
      CCDS53102.1
      UniProtKB/TrEMBL
      Q3V4D5, Q8R2U5
      Related
      ENSMUSP00000110031.4, ENSMUST00000114389.10
      Conserved Domains (2) summary
      COG0456
      Location:1149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47122
      Acetyltransf_1; Acetyltransferase (GNAT) family
    2. NM_001310538.1NP_001297467.1  N-alpha-acetyltransferase 10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK003806, BY101790, CN666135
      Consensus CDS
      CCDS81139.1
      UniProtKB/TrEMBL
      B1AUY9
      Related
      ENSMUSP00000110029.2, ENSMUST00000114387.8
      Conserved Domains (1) summary
      COG0456
      Location:1149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    3. NM_019870.3NP_063923.1  N-alpha-acetyltransferase 10 isoform 1

      See identical proteins and their annotated locations for NP_063923.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript but encodes the longest isoform (1).
      Source sequence(s)
      AL672002
      Consensus CDS
      CCDS30217.1
      UniProtKB/Swiss-Prot
      Q9QY36
      UniProtKB/TrEMBL
      B1AUY7, Q540H0
      Related
      ENSMUSP00000033763.9, ENSMUST00000033763.15
      Conserved Domains (1) summary
      COG0456
      Location:1149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72960476..72965550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162037.1XP_036017930.1  N-alpha-acetyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      Q684Q8
      Conserved Domains (1) summary
      COG0456
      Location:15138
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    2. XM_036162039.1XP_036017932.1  N-alpha-acetyltransferase 10 isoform X3

      Conserved Domains (1) summary
      COG0456
      Location:15138
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    3. XM_036162038.1XP_036017931.1  N-alpha-acetyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      Q8R2U5
      Conserved Domains (1) summary
      COG0456
      Location:15138
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_004940354.1 RNA Sequence

    2. XR_003953017.2 RNA Sequence