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    Sox7 SRY-box transcription factor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290317, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sox7provided by RGD
    Official Full Name
    SRY-box transcription factor 7provided by RGD
    Primary source
    RGD:1310038
    See related
    EnsemblRapid:ENSRNOG00000012049 AllianceGenome:RGD:1310038
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including endoderm formation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human SOX7 (SRY-box transcription factor 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 97.1), Heart (RPKM 50.2) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Sox7 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (42356405..42363166)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (38180503..38187264)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (47293699..47300460)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482131 Neighboring gene PIN2/TERF1 interacting, telomerase inhibitor 1 Neighboring gene uncharacterized LOC102549097 Neighboring gene similar to human chromosome 8 open reading frame 74 Neighboring gene uncharacterized LOC120097016 Neighboring gene RP1 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription factor SOX-7
    Names
    SRY (sex determining region Y)-box 7
    SRY box 7
    SRY-box containing gene 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106045.1NP_001099515.1  transcription factor SOX-7

      See identical proteins and their annotated locations for NP_001099515.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474023
      UniProtKB/TrEMBL
      A6K6G8, D3ZTE1
      Related
      ENSRNOP00000016503.4, ENSRNOT00000016503.6
      Conserved Domains (2) summary
      cd01388
      Location:44115
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam12067
      Location:178381
      Sox_C_TAD; Sox C-terminal transactivation domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      42356405..42363166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)