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    Mtmr4 myotubularin related protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287607, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mtmr4provided by RGD
    Official Full Name
    myotubularin related protein 4provided by RGD
    Primary source
    RGD:1310306
    See related
    EnsemblRapid:ENSRNOG00000007496 AllianceGenome:RGD:1310306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including R-SMAD binding activity; phosphatidylinositol phosphate phosphatase activity; and protein phosphatase binding activity. Involved in response to denervation involved in regulation of muscle adaptation. Predicted to be located in early endosome membrane; late endosome membrane; and recycling endosome membrane. Predicted to be active in early phagosome membrane and endosome membrane. Biomarker of muscular atrophy. Orthologous to human MTMR4 (myotubularin related protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 186.2), Brain (RPKM 153.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mtmr4 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72890665..72913598)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72393411..72416342)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74886600..74909532)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene testis expressed 14, intercellular bridge forming factor Neighboring gene uncharacterized LOC134480848 Neighboring gene septin 4 Neighboring gene heat shock transcription factor 5 Neighboring gene ring finger protein 43 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in early phagosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myotubularin-related protein 4
    NP_001099297.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105827.4NP_001099297.4  myotubularin-related protein 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AT43, D3ZW40
      Related
      ENSRNOP00000086395.2, ENSRNOT00000099688.2
      Conserved Domains (3) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11071166
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:127519
      Myotub-related; Myotubularin-like phosphatase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      72890665..72913598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)