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    Trpv2 transient receptor potential cation channel, subfamily V, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 22368, updated on 27-Nov-2024

    Summary

    Official Symbol
    Trpv2provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily V, member 2provided by MGI
    Primary source
    MGI:MGI:1341836
    See related
    Ensembl:ENSMUSG00000018507 AllianceGenome:MGI:1341836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GRC; Vrl1; VRL-1; OTRPC2
    Summary
    Enables calcium channel activity. Involved in positive regulation of axon extension; positive regulation of calcium ion import; and positive regulation of cold-induced thermogenesis. Located in cell body; cell surface; and growth cone. Is expressed in central nervous system; dorsal root ganglion; sensory organ; and testis. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 24.2), placenta adult (RPKM 13.8) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Trpv2 in Genome Data Viewer
    Location:
    11 B2; 11 38.48 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62465312..62491131)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62574486..62600305)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12279 Neighboring gene STARR-seq mESC enhancer starr_29713 Neighboring gene ubiquitin B Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:62387853-62388036 Neighboring gene RIKEN cDNA 2410006H16 gene Neighboring gene STARR-positive B cell enhancer ABC_E9364 Neighboring gene small nucleolar RNA, C/D box 49B Neighboring gene small nucleolar RNA, C/D box 49A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    transient receptor potential cation channel subfamily V member 2
    Names
    growth factor regulated channel
    growth factor-regulated calcium channel
    osm-9-like TRP channel 2
    vanilloid receptor-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382489.1NP_001369418.1  transient receptor potential cation channel subfamily V member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596181
      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Conserved Domains (2) summary
      sd00045
      Location:158189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2
    2. NM_001382490.1NP_001369419.1  transient receptor potential cation channel subfamily V member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596181
      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Conserved Domains (2) summary
      sd00045
      Location:158189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2
    3. NM_001382491.1NP_001369420.1  transient receptor potential cation channel subfamily V member 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596181
      Conserved Domains (2) summary
      sd00045
      Location:158189
      ANK; ANK repeat [structural motif]
      cl40437
      Location:66658
      TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
    4. NM_001382492.1NP_001369421.1  transient receptor potential cation channel subfamily V member 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL596181
      Conserved Domains (2) summary
      sd00045
      Location:158189
      ANK; ANK repeat [structural motif]
      cl40437
      Location:66647
      TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
    5. NM_011706.2NP_035836.2  transient receptor potential cation channel subfamily V member 2 isoform 1

      See identical proteins and their annotated locations for NP_035836.2

      Status: VALIDATED

      Source sequence(s)
      AK008689, BB631765, BY648241
      Consensus CDS
      CCDS24827.1
      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Related
      ENSMUSP00000018651.8, ENSMUST00000018651.14
      Conserved Domains (2) summary
      sd00045
      Location:158189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62465312..62491131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156630.1XP_036012523.1  transient receptor potential cation channel subfamily V member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Related
      ENSMUSP00000099703.2, ENSMUST00000102643.2
      Conserved Domains (2) summary
      sd00045
      Location:158189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2