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    Atp23 ATP23 metallopeptidase and ATP synthase assembly factor homolog [ Mus musculus (house mouse) ]

    Gene ID: 68876, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atp23provided by MGI
    Official Full Name
    ATP23 metallopeptidase and ATP synthase assembly factor homologprovided by MGI
    Primary source
    MGI:MGI:1916984
    See related
    Ensembl:ENSMUSG00000025436 AllianceGenome:MGI:1916984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xrcc6bp1; 1110068E08Rik; 2410012H02Rik
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing and mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be located in several cellular components, including cell junction; cytosol; and plasma membrane. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human ATP23 (ATP23 metallopeptidase and ATP synthase assembly factor homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 1.5), limb E14.5 (RPKM 1.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp23 in Genome Data Viewer
    Location:
    10 D3; 10 73.84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126703698..126737893, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (126867829..126902024, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28191 Neighboring gene predicted gene, 24179 Neighboring gene STARR-seq mESC enhancer starr_28192 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1409 Neighboring gene STARR-seq mESC enhancer starr_28193 Neighboring gene predicted gene, 30456 Neighboring gene predicted gene, 30539

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway. Yang G, et al. Int J Mol Sci, 2022 May 27. PMID 35682694, Free PMC Article
    2. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial inner membrane protease ATP23 homolog
    Names
    XRCC6 binding protein 1
    NP_001153031.1
    NP_001345898.1
    NP_001345899.1
    NP_081134.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159559.1 → NP_001153031.1  mitochondrial inner membrane protease ATP23 homolog isoform 1

      See identical proteins and their annotated locations for NP_001153031.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in its 3' terminal exon compared to variant 4. The encoded isoform (1) has a shorter and distinct C-terminus compared to isoform 4.
      Source sequence(s)
      AK004405, BG801921, CB203044
      Consensus CDS
      CCDS48710.1
      UniProtKB/TrEMBL
      G3UW46
      Related
      ENSMUSP00000128382.2, ENSMUST00000168520.3
      Conserved Domains (1) summary
      pfam09768
      Location:50 → 220
      Peptidase_M76; Peptidase M76 family

    2. NM_001358969.1 → NP_001345898.1  mitochondrial inner membrane protease ATP23 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in its 3' terminal exon, resulting in a frameshift compared to variant 4. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 4.
      Source sequence(s)
      AA221211, AC122018, BE863276, BY704635, CB203044
      Conserved Domains (1) summary
      pfam09768
      Location:50 → 179
      Peptidase_M76; Peptidase M76 family

    3. NM_001358970.1 → NP_001345899.1  mitochondrial inner membrane protease ATP23 homolog isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform.
      Source sequence(s)
      AA221211, AC122018, AK039002, BE863276, BY704635, CB203044
      Related
      ENSMUST00000220051.2
      Conserved Domains (1) summary
      pfam09768
      Location:50 → 179
      Peptidase_M76; Peptidase M76 family

    4. NM_026858.3 → NP_081134.2  mitochondrial inner membrane protease ATP23 homolog isoform 2

      See identical proteins and their annotated locations for NP_081134.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' exon compared to variant 4. The encoded isoform (2)is shorter and has a distinct C-terminus compared to isoform 4.
      Source sequence(s)
      BC030630, BG801921
      Consensus CDS
      CCDS24220.1
      UniProtKB/Swiss-Prot
      Q9CWQ3
      Related
      ENSMUSP00000026504.6, ENSMUST00000026504.13
      Conserved Domains (1) summary
      pfam09768
      Location:50 → 192
      Peptidase_M76; Peptidase M76 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      126703698..126737893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003948791.2 RNA Sequence

    2. XR_003948790.1 RNA Sequence

    3. XR_004936268.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWQ3.1 GenPept UniProtKB/Swiss-Prot:Q9CWQ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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