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    Nrg3 neuregulin 3 [ Mus musculus (house mouse) ]

    Gene ID: 18183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrg3provided by MGI
    Official Full Name
    neuregulin 3provided by MGI
    Primary source
    MGI:MGI:1097165
    See related
    Ensembl:ENSMUSG00000041014 AllianceGenome:MGI:1097165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ska
    Summary
    Enables chemorepellent activity. Involved in ERBB4-ERBB4 signaling pathway and synapse assembly. Acts upstream of or within several processes, including intracellular signal transduction; mammary placode formation; and regulation of cell migration. Is active in extracellular space and glutamatergic synapse. Is expressed in several structures, including embryo mesenchyme; epidermis; mammary gland primordium; nervous system; and testis. Used to study schizophrenia. Orthologous to human NRG3 (neuregulin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 4.1), frontal lobe adult (RPKM 3.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nrg3 in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (38086093..39195045, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (38365102..39473235, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36433 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36435 Neighboring gene STARR-seq mESC enhancer starr_36436 Neighboring gene STARR-seq mESC enhancer starr_36437 Neighboring gene STARR-seq mESC enhancer starr_36439 Neighboring gene predicted gene, 31456 Neighboring gene STARR-seq mESC enhancer starr_36440 Neighboring gene STARR-seq mESC enhancer starr_36441 Neighboring gene cytochrome c oxidase, subunit VIIc pseudogene Neighboring gene STARR-seq mESC enhancer starr_36442 Neighboring gene STARR-seq mESC enhancer starr_36443 Neighboring gene STARR-seq mESC enhancer starr_36444 Neighboring gene predicted gene, 53854 Neighboring gene STARR-seq mESC enhancer starr_36445 Neighboring gene neuregulin 3, opposite strand Neighboring gene STARR-seq mESC enhancer starr_36446 Neighboring gene STARR-seq mESC enhancer starr_36447 Neighboring gene predicted gene 20642 Neighboring gene predicted gene, 31606 Neighboring gene uncharacterized LOC432842 Neighboring gene potassium channel modulatory factor 1 pseudogene Neighboring gene RIKEN cDNA 1700109I08 gene Neighboring gene STARR-seq mESC enhancer starr_36448 Neighboring gene predicted gene, 35389

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action. Loos M, et al. Biol Psychiatry, 2014 Oct 15. PMID 24703509
    2. Neuregulin 3 Knockout Mice Exhibit Behaviors Consistent with Psychotic Disorders. Hayes LN, et al. Mol Neuropsychiatry, 2016 Jul. PMID 27606322, Free PMC Article
    3. The characterization of a mouse mutant that displays abnormal mammary gland development. Howard BA, et al. Mamm Genome, 2000 Mar. PMID 10723730
    4. [Neuregulin promotes spermatogonia proliferation in mice]. Jin YJ, et al. Zhonghua Nan Ke Xue, 2011 May. PMID 21837948
    5. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Wang YN, et al. Proc Natl Acad Sci U S A, 2018 Mar 6. PMID 29463705, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.
      Title: In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.
    2. Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits.
      Title: Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits.
    3. data indicate that Nrg3 provides adhesive cues that facilitate excitatory neurons to synapse onto ErbB4(+) interneurons.
      Title: Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.
    4. Studied the physiologic role of neuregulin3 (NRG3) in regulating glutamatergic transmission in pyramidal neurons. Found NRG3 regulates the SNARE-complex assembly, and NRG3 knockout causes display behavior deficits related to mental illness.
      Title: Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex.
    5. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits.
      Title: Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons.
    6. This study demonistrated that Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
      Title: Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
    7. NRG1beta and NRG3 can promote the proliferation of mouse spermatogonia.
      Title: [Neuregulin promotes spermatogonia proliferation in mice].
    8. used positional cloning to narrow the interval containing scaramanga (ska) to a 75.6-kb interval containing the distal part of the Neuregulin3 (Nrg3) gene
      Title: Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification.
    9. a Neuregulin3 signaling pathway is involved in specification of mammary gland morphogenesis
      Title: Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemorepellent activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERBB4 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERBB4 signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in ERBB4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in ERBB4-ERBB4 signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chemorepulsion involved in interneuron migration from the subpallium to the cortex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary placode formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pro-neuregulin-3, membrane-bound isoform
    Names
    pro-NRG3
    scaramanga

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190187.1 → NP_001177116.1  pro-neuregulin-3, membrane-bound isoform isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC109253, AC154426, CT025583, CT025629, CT030231
      UniProtKB/TrEMBL
      B9EHF8
      Conserved Domains (2) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:354 → 401
      Neuregulin; Neuregulin family

    2. NM_001190188.1 → NP_001177117.1  pro-neuregulin-3, membrane-bound isoform isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC109253, AC154426, CT025583, CT025629, CT030231
      Consensus CDS
      CCDS49450.1
      UniProtKB/TrEMBL
      B7ZN23, E9Q396
      Related
      ENSMUSP00000129783.3, ENSMUST00000168810.9
      Conserved Domains (2) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:355 → 402
      Neuregulin; Neuregulin family

    3. NM_008734.3 → NP_032760.1  pro-neuregulin-3, membrane-bound isoform isoform 1

      See identical proteins and their annotated locations for NP_032760.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC109253, AC154426, CT025583, CT025629, CT030231
      Consensus CDS
      CCDS26954.1
      UniProtKB/Swiss-Prot
      O35181
      UniProtKB/TrEMBL
      B9EHF8
      Related
      ENSMUSP00000136884.2, ENSMUST00000166968.9
      Conserved Domains (2) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:355 → 402
      Neuregulin; Neuregulin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      38086093..39195045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158506.1 → XP_036014399.1  pro-neuregulin-3, membrane-bound isoform isoform X9

      UniProtKB/TrEMBL
      B7ZN23
      Conserved Domains (1) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional

    2. XM_006518687.5 → XP_006518750.1  pro-neuregulin-3, membrane-bound isoform isoform X7

      UniProtKB/TrEMBL
      B7ZN23
      Conserved Domains (2) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional
      COG5160
      Location:351 → 563
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    3. XM_036158505.1 → XP_036014398.1  pro-neuregulin-3, membrane-bound isoform isoform X4

      UniProtKB/TrEMBL
      B9EHF8
      Conserved Domains (1) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional

    4. XM_030247684.2 → XP_030103544.1  pro-neuregulin-3, membrane-bound isoform isoform X5

      UniProtKB/TrEMBL
      B7ZN23
      Conserved Domains (2) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional
      COG5160
      Location:351 → 564
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    5. XM_011244987.4 → XP_011243289.1  pro-neuregulin-3, membrane-bound isoform isoform X2

      UniProtKB/TrEMBL
      B9EHF8
      Conserved Domains (1) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional

    6. XM_017315911.3 → XP_017171400.1  pro-neuregulin-3, membrane-bound isoform isoform X8

      UniProtKB/TrEMBL
      B7ZN23, G3V023
      Related
      ENSMUSP00000134727.2, ENSMUST00000173780.2
      Conserved Domains (1) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional

    7. XM_006518686.5 → XP_006518749.1  pro-neuregulin-3, membrane-bound isoform isoform X6

      UniProtKB/TrEMBL
      B7ZN23
      Conserved Domains (2) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional
      COG5160
      Location:352 → 564
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    8. XM_006518685.5 → XP_006518748.1  pro-neuregulin-3, membrane-bound isoform isoform X3

      UniProtKB/TrEMBL
      B9EHF8
      Conserved Domains (1) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional

    9. XM_017315910.3 → XP_017171399.1  pro-neuregulin-3, membrane-bound isoform isoform X1

      UniProtKB/TrEMBL
      B9EHF8
      Conserved Domains (1) summary
      PHA02887
      Location:280 → 333
      PHA02887; EGF-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35181.1 GenPept UniProtKB/Swiss-Prot:O35181

    Gene LinkOut

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