Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Pr55(Gag)
|
gag
|
Loss of PPM1G expression by siRNA results in downregulation of HIV-1 Gag production in cells and CA in virions, indicating that HIV-1 transcription is regulated by PPM1G |
PubMed
|
Tat
|
tat
|
HIV-1 Tat binds PPM1G and the activation domain (residues 1-48) of Tat and the acidic domain of PPM1G are required to the binding. Tat mutant K41A abolishes the binding |
PubMed
|
|
tat
|
HIV-1 Tat recruits PPM1G phosphatase protein to dephosphorylate the T loop of CDK9 and release P-TEFb from the 7SK snRNP complex |
PubMed
|
|
tat
|
HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription |
PubMed
|
|
tat
|
HIV-1 Tat is identified to have a physical interaction with protein phosphatase, Mg2+/Mn2+ dependent, 1G (PPM1G) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses |
PubMed
|
capsid
|
gag
|
Loss of PPM1G expression by siRNA results in downregulation of HIV-1 Gag production in cells and CA in virions, indicating that HIV-1 transcription is regulated by PPM1G |
PubMed
|
Go to the HIV-1, Human Interaction Database