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    CYP4A11 cytochrome P450 family 4 subfamily A member 11 [ Homo sapiens (human) ]

    Gene ID: 1579, updated on 10-Dec-2024

    Summary

    Official Symbol
    CYP4A11provided by HGNC
    Official Full Name
    cytochrome P450 family 4 subfamily A member 11provided by HGNC
    Primary source
    HGNC:HGNC:2642
    See related
    Ensembl:ENSG00000187048 MIM:601310; AllianceGenome:HGNC:2642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CP4Y; CYP4A2; CYP4AII; CYPIVA11
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in liver (RPKM 280.4) and kidney (RPKM 130.2) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CYP4A11 in Genome Data Viewer
    Location:
    1p33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46929188..46941476, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46806597..46818885, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47394860..47407148, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily B member 1 Neighboring gene cytochrome P450 family 4 subfamily Z member 2, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47327255-47327861 Neighboring gene tubulin alpha pseudogene 8 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:47434192-47434383 Neighboring gene cytochrome P450 family 4 subfamily A member 26, pseudogene Neighboring gene cytochrome P450 family 4 subfamily X member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47449029-47449836 Neighboring gene cytochrome P450 family 4 subfamily A member 43, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (12 hits/1253 screens)

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Human metabolic individuality in biomedical and pharmaceutical research.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in arachidonate metabolic process  
    involved_in arachidonate metabolic process PubMed 
    involved_in epoxygenase P450 pathway PubMed 
    involved_in fatty acid metabolic process  
    involved_in icosanoid biosynthetic process  
    involved_in kidney development  
    involved_in lauric acid metabolic process  
    involved_in leukotriene B4 catabolic process  
    involved_in leukotriene metabolic process PubMed 
    involved_in linoleic acid metabolic process  
    involved_in long-chain fatty acid metabolic process PubMed 
    involved_in omega-hydroxylase P450 pathway  
    involved_in oxylipin biosynthetic process  
    involved_in positive regulation of icosanoid secretion PubMed 
    involved_in pressure natriuresis PubMed 
    involved_in renal water homeostasis PubMed 
    involved_in sodium ion homeostasis PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in cytoplasm PubMed 
    located_in endoplasmic reticulum membrane  
    is_active_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle PubMed 

    General protein information

    Preferred Names
    cytochrome P450 4A11
    Names
    20-HETE synthase
    20-hydroxyeicosatetraenoic acid synthase
    P450HL-omega
    alkane-1 monooxygenase
    cytochrome P-450HK-omega
    cytochrome P450, family 4, subfamily A, polypeptide 11
    cytochrome P450, subfamily IVA, polypeptide 11
    cytochrome P450HL-omega
    fatty acid omega-hydroxylase
    lauric acid omega-hydroxylase
    long-chain fatty acid omega-monooxygenase
    NP_000769.2
    NP_001306084.1
    NP_001350516.1
    XP_005270596.1
    XP_016855954.1
    XP_054190680.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007932.1 RefSeqGene

      Range
      5009..17297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000778.4 → NP_000769.2  cytochrome P450 4A11 isoform 1

      See identical proteins and their annotated locations for NP_000769.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL731892, CD014132, D26481, S67580
      Consensus CDS
      CCDS543.1
      UniProtKB/Swiss-Prot
      Q02928, Q06766, Q16865, Q16866, Q5VSP8, Q86SU6, Q8IWY5
      UniProtKB/TrEMBL
      Q16802
      Related
      ENSP00000311095.4, ENST00000310638.9
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 505
      p450; Cytochrome P450
    2. NM_001319155.2 → NP_001306084.1  cytochrome P450 4A11 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL731892, CD013974, L04751
      UniProtKB/TrEMBL
      Q16802
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 473
      p450; Cytochrome P450
    3. NM_001363587.2 → NP_001350516.1  cytochrome P450 4A11 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) has multiple differences in the coding region compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL731892
      Consensus CDS
      CCDS85973.1
      UniProtKB/TrEMBL
      A5PL05, V9GZ77
      Related
      ENSP00000477495.1, ENST00000462347.5
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 407
      p450; Cytochrome P450

    RNA

    1. NR_134988.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL731892, CD013975, L04751
    2. NR_134989.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL731892, CD013976, L04751
    3. NR_134990.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL731892, CD013977, L04751
    4. NR_134991.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL731892, CD013978, L04751
    5. NR_134992.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks four alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL731892, CD013979, L04751
    6. NR_134993.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks three alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL731892, CD013980, L04751
      Related
      ENST00000475477.5
    7. NR_134994.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL731892, CD014132, L04751

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      46929188..46941476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000465.2 → XP_016855954.1  cytochrome P450 4A11 isoform X1

      UniProtKB/TrEMBL
      B4DPB8
    2. XM_005270539.1 → XP_005270596.1  cytochrome P450 4A11 isoform X2

      UniProtKB/TrEMBL
      A5PL05
      Conserved Domains (1) summary
      cl12078
      Location:52 → 357
      p450; Cytochrome P450

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      46806597..46818885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334705.1 → XP_054190680.1  cytochrome P450 4A11 isoform X1

      UniProtKB/TrEMBL
      B4DPB8
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