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    NPEPPSP1 NPEPPS pseudogene 1 [ Homo sapiens (human) ]

    Gene ID: 440434, updated on 10-Dec-2024

    Summary

    Official Symbol
    NPEPPSP1provided by HGNC
    Official Full Name
    NPEPPS pseudogene 1provided by HGNC
    Primary source
    HGNC:HGNC:44259
    See related
    Ensembl:ENSG00000291088 AllianceGenome:HGNC:44259
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPEPPSL1
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 24.1), skin (RPKM 20.6) and 25 other tissues See more
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    Genomic context

    See NPEPPSP1 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38195740..38257249, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39058811..39120263, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36351796..36413256, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon pseudogene 6 Neighboring gene TBC1 domain family member 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36380303-36380804 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36399387-36399886 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36413044-36413577 Neighboring gene uncharacterized LOC105371760 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:36442025-36443224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36452469-36453018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36453019-36453569 Neighboring gene mitochondrial ribosomal protein L45 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36476257-36477193

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    General gene information

    Other Names

    • Puromycin-sensitive aminopeptidase-like protein
    • aminopeptidase puromycin sensitive pseudogene

    Clone Names

    • FLJ11822, FLJ57364, FLJ58835, FLJ77836

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity  
    enables peptide binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in peptide catabolic process  
    involved_in proteolysis  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in extracellular exosome PubMed 
    is_active_in extracellular space  
    is_active_in membrane  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_036750.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC244092, AC244154
      Related
      ENST00000685611.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      38195740..38257249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      2230861..2292321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      39058811..39120263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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