LRO1 phospholipid:diacylglycerol acyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: LRO1
Official Full Name: phospholipid:diacylglycerol acyltransferase
Primary source: SGD:S000005291
Locus tag: YNR008W
See related: AllianceGenome:SGD:S000005291; FungiDB:YNR008W; VEuPathDB:YNR008W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phospholipid:diacylglycerol acyltransferase activity. Involved in several processes, including lipid storage; phospholipid homeostasis; and triglyceride biosynthetic process. Located in lipid droplet; nuclear inner membrane; and perinuclear endoplasmic reticulum. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase) and PLA2G15 (phospholipase A2 group XV). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See LRO1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (640396..642381)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid:diacylglycerol acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid:diacylglycerol acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid:diacylglycerol acyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ceramide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipid:diacylglycerol acyltransferase

NP_014405.1

EC 2.3.1.158

Acyltransferase that converts diacylglycerol to triacylglycerol (TGA); one of several acyltransferases that contribute to TGA synthesis; relocates from ER to nuclear membrane in response cell cycle and starvation signals; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

640396..642381

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183185.1 → NP_014405.1 TPA: phospholipid:diacylglycerol acyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014405.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1I3, P40345

UniProtKB/TrEMBL

A6ZS82, B3LPN2, C7GLP7, C8ZFN5, G2WL65, N1NZN8

Conserved Domains (1) summary

pfam02450
Location:206 → 625

LCAT; Lecithin:cholesterol acyltransferase