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    Ptgis prostaglandin I2 (prostacyclin) synthase [ Mus musculus (house mouse) ]

    Gene ID: 19223, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ptgisprovided by MGI
    Official Full Name
    prostaglandin I2 (prostacyclin) synthaseprovided by MGI
    Primary source
    MGI:MGI:1097156
    See related
    Ensembl:ENSMUSG00000017969 AllianceGenome:MGI:1097156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyp8; Pgis; Cyp8a1
    Summary
    Predicted to enable heme binding activity and prostaglandin-I synthase activity. Acts upstream of or within decidualization and embryo implantation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; ear; early embryo; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); colorectal adenoma; limb ischemia; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 56.6), ovary adult (RPKM 52.9) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ptgis in Genome Data Viewer
    Location:
    2 H3; 2 87.22 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (167045114..167095069, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167203194..167252150, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene potassium voltage gated channel, Shab-related subfamily, member 1 Neighboring gene predicted gene, 52568 Neighboring gene RIKEN cDNA 1110018N20 gene Neighboring gene predicted gene, 52569 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 Neighboring gene STARR-positive B cell enhancer ABC_E2061 Neighboring gene STARR-positive B cell enhancer ABC_E7887 Neighboring gene STARR-positive B cell enhancer ABC_E419 Neighboring gene STARR-positive B cell enhancer mm9_chr2:167200540-167200841 Neighboring gene STARR-positive B cell enhancer ABC_E4522 Neighboring gene STARR-seq mESC enhancer starr_06429 Neighboring gene STARR-positive B cell enhancer ABC_E7888 Neighboring gene STARR-seq mESC enhancer starr_06433 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hydroperoxy icosatetraenoate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    enables prostaglandin-I synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prostaglandin-I synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables prostaglandin-I synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to interleukin-1 ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to interleukin-6 ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within decidualization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryo implantation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in icosanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in icosanoid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of execution phase of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in prostaglandin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    prostacyclin synthase
    Names
    hydroperoxy icosatetraenoate dehydratase
    NP_001407681.1
    NP_001407682.1
    NP_001407683.1
    NP_001407684.1
    NP_001407685.1
    NP_032994.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420752.1NP_001407681.1  prostacyclin synthase isoform b

      Status: VALIDATED

      Source sequence(s)
      AL591854
      UniProtKB/TrEMBL
      Q8BXC0
    2. NM_001420753.1NP_001407682.1  prostacyclin synthase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL591854
    3. NM_001420754.1NP_001407683.1  prostacyclin synthase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL591854
    4. NM_001420755.1NP_001407684.1  prostacyclin synthase isoform c

      Status: VALIDATED

      Source sequence(s)
      AL591854
    5. NM_001420756.1NP_001407685.1  prostacyclin synthase isoform d

      Status: VALIDATED

      Source sequence(s)
      AL591854
    6. NM_008968.5NP_032994.1  prostacyclin synthase isoform a

      See identical proteins and their annotated locations for NP_032994.1

      Status: VALIDATED

      Source sequence(s)
      AL591854
      Consensus CDS
      CCDS17097.1
      UniProtKB/Swiss-Prot
      O35074
      UniProtKB/TrEMBL
      Q8BXC0
      Related
      ENSMUSP00000018113.8, ENSMUST00000018113.8
      Conserved Domains (1) summary
      cl12078
      Location:28490
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      167045114..167095069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)