PGP phosphoglycolate phosphatase [Homo sapiens (human)] - Gene

Summary

Official Symbol: PGPprovided by HGNC
Official Full Name: phosphoglycolate phosphataseprovided by HGNC
Primary source: HGNC:HGNC:8909
See related: Ensembl:ENSG00000184207 MIM:172280; AllianceGenome:HGNC:8909
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AUM; G3PP; PGPase
Summary: Enables glycerol-3-phosphatase activity and phosphoglycolate phosphatase activity. Involved in glycerol biosynthetic process; glycerophospholipid metabolic process; and negative regulation of gluconeogenesis. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis (RPKM 12.7), brain (RPKM 7.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (2211593..2214840, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (2234051..2237302, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (2261594..2264841, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exploring the dynamics of the ABCB1 membrane transporter P-glycoprotein in the presence of ATP and active/non-active compounds through molecular dynamics simulations.
Title: Exploring the dynamics of the ABCB1 membrane transporter P-glycoprotein in the presence of ATP and active/non-active compounds through molecular dynamics simulations.
Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes.
Title: Exome-Wide Association Study Identifies FN3KRP and PGP as New Candidate Longevity Genes.
data explain how PGP exerts control over EGF-induced cellular protein tyrosine phosphorylation, and reveal an unexpected influence of triacylglycerol turnover on growth factor signaling.
Title: A phosphoglycolate phosphatase/AUM-dependent link between triacylglycerol turnover and epidermal growth factor signaling.
Phosphoglycolate phosphatase rescues central carbon metabolism from toxic secondary metabolites in humans and yeast.
Title: A Guardian Angel Phosphatase for Mainline Carbon Metabolism.
Data indicate that Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance (MDR) via utilization of lysosomal P-glycoprotein (Pgp) transport activity.
Title: Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).
acute myeloid leukemia patients with co-expression of PGP and Ly showed better overall survival compared with PGP(+) patients without Ly expression
Title: Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results.
expressed in skin lesions from groins and axilla in patients with hidradenitis suppurativa
Title: Cutaneous PGP 9.5 distribution patterns in hidradenitis suppurativa.
the PI3K/Akt pathway is involved in MDR in lymphoma cell lines and PI3K/Akt inhibition correlates down-regulation of NF-kappaB activity and inhibition Pgp function.
Title: PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.
Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: The relationship between P-glycoprotein (PGP) polymorphisms and response to olanzapine treatment in schizophrenia.
Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bdac6f06 (e-PCR)
- UniSTS:75784

STS-W86181 (e-PCR)
- UniSTS:15146

RH98228 (e-PCR)
- UniSTS:91450

G60043 (e-PCR)
- UniSTS:137306

D16S2568E (e-PCR)
- UniSTS:151651

AI481330 (e-PCR)
- UniSTS:160626

WIAF-1628 (e-PCR)
- UniSTS:76494

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ADP phosphatase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-3-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycolate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in glycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerophospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycerol-3-phosphate phosphatase

Names: aspartate-based ubiquitous Mg(2+)-dependent phosphatase

NP_001035830.1

EC 3.1.3.21

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042371.3 → NP_001035830.1 glycerol-3-phosphate phosphatase

See identical proteins and their annotated locations for NP_001035830.1

Status: VALIDATED

Source sequence(s)

AC009065, AK026146, AW161386, BC035985, DA336356

Consensus CDS

CCDS42104.1

UniProtKB/Swiss-Prot

A6NDG6

Related

ENSP00000330918.7, ENST00000333503.8

Conserved Domains (3) summary

TIGR01452
Location:28 → 315

PGP_euk; phosphoglycolate/pyridoxal phosphate phosphatase family

pfam13242
Location:232 → 315

Hydrolase_like; HAD-hyrolase-like

pfam13344
Location:31 → 138

Hydrolase_6; Haloacid dehalogenase-like hydrolase