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    TEDC2 tubulin epsilon and delta complex 2 [ Homo sapiens (human) ]

    Gene ID: 80178, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TEDC2provided by HGNC
    Official Full Name
    tubulin epsilon and delta complex 2provided by HGNC
    Primary source
    HGNC:HGNC:25849
    See related
    Ensembl:ENSG00000162062 AllianceGenome:HGNC:25849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C16orf59
    Summary
    Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in centriole and cilium. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 2.6), bone marrow (RPKM 1.5) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TEDC2 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2460109..2464963)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2482238..2487092)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2510110..2514964)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cyclin F Neighboring gene microRNA 6767 Neighboring gene uncharacterized LOC105371050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2508584-2509398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10267 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7048 Neighboring gene TEDC2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2518620-2519163 Neighboring gene microRNA 6768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10269 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7055 Neighboring gene netrin 3 Neighboring gene TBC1 domain family member 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2532873-2533374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2533375-2533874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2546817-2547422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2550095-2550912

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. A pan-cancer analysis of the prognostic implication and oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors. Liu Y, et al. Front Immunol, 2023. PMID 38239349, Free PMC Article
    2. TEDC2 plays an oncogenic role and serves as a therapeutic target of hepatocellular carcinoma. Li Y, et al. Dig Liver Dis, 2024 May. PMID 37867019
    3. TEDC2 correlated with prognosis and immune microenvironment in lung adenocarcinoma. Fang L, et al. Sci Rep, 2023 Mar 27. PMID 36973475, Free PMC Article
    4. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. Assmann EM, et al. J Biol Chem, 2006 Apr 14. PMID 16484223
    5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TEDC2 plays an oncogenic role and serves as a therapeutic target of hepatocellular carcinoma.
      Title: TEDC2 plays an oncogenic role and serves as a therapeutic target of hepatocellular carcinoma.
    2. A pan-cancer analysis of the prognostic implication and oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors.
      Title: A pan-cancer analysis of the prognostic implication and oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors.
    3. TEDC2 correlated with prognosis and immune microenvironment in lung adenocarcinoma.
      Title: TEDC2 correlated with prognosis and immune microenvironment in lung adenocarcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13909

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin epsilon and delta complex protein 2
    Names
    uncharacterized protein C16orf59

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025108.3 → NP_079384.2  tubulin epsilon and delta complex protein 2

      See identical proteins and their annotated locations for NP_079384.2

      Status: VALIDATED

      Source sequence(s)
      AC106820, AL559561, BC018719
      Consensus CDS
      CCDS10468.2
      UniProtKB/Swiss-Prot
      B4DXD7, Q7L2K0, Q96H61, Q9H872
      UniProtKB/TrEMBL
      H3BND0
      Related
      ENSP00000355022.4, ENST00000361837.9
      Conserved Domains (1) summary
      pfam15764
      Location:148 → 431
      DUF4693; Domain of unknown function (DUF4693)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2460109..2464963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522667.2 → XP_011520969.1  tubulin epsilon and delta complex protein 2 isoform X1

      UniProtKB/TrEMBL
      H3BND0
      Conserved Domains (1) summary
      pfam15764
      Location:115 → 398
      DUF4693; Domain of unknown function (DUF4693)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2482238..2487092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314002.1 → XP_054169977.1  tubulin epsilon and delta complex protein 2 isoform X1

      UniProtKB/TrEMBL
      H3BND0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L2K0.1 GenPept UniProtKB/Swiss-Prot:Q7L2K0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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