WTIP WT1 interacting protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: WTIPprovided by HGNC
Official Full Name: WT1 interacting proteinprovided by HGNC
Primary source: HGNC:HGNC:20964
See related: Ensembl:ENSG00000142279 MIM:614790; AllianceGenome:HGNC:20964
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable transcription corepressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of hippo signaling; and response to hypoxia. Acts upstream of or within miRNA-mediated post-transcriptional gene silencing. Located in P-body. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in fat (RPKM 6.5), ovary (RPKM 5.4) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (34481758..34512304)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (37026321..37056847)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (34972663..35003209)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy.
Title: Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy.
WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia.
Title: WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia.
The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway.
Title: The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway.
WTIP impairs AKT phosphorylation and activation, leading to enhanced expression and transcriptional activity of FOXO1, which further increases p21Cip1 and p27Kip1, and decreases cyclin D1, which consequently results in cell cycle arrest.
Title: WT1-interacting protein inhibits cell proliferation and tumorigenicity in non-small-cell lung cancer via the AKT/FOXO1 axis.
The findings suggest that the UBA2-WTIP fusion is an oncogenic fusion gene, as well as a promising therapeutic target for the treatment of acute myeloid leukemia.
Title: Identification of the UBA2-WTIP fusion gene in acute myeloid leukemia.
We show that all three mammalian Ajuba family proteins - AJUBA, LIMD1 and WTIP - exhibit tension-dependent localization to adherens junctions, and that both LATS family proteins, LATS1 and LATS2, exhibit an overlapping tension-dependent junctional localization
Title: Tension-dependent regulation of mammalian Hippo signaling through LIMD1.
WTIP interacts with BRCA2 and might be responsible for BRCA2 centrosome localization in cervical cancer cell.
Title: WTIP interacts with BRCA2 and is essential for BRCA2 centrosome localization in cervical cancer cell.
Nck1 and Nck2 Interact with WTIP. Nck1/2 integrates nephrin with the Hippo kinase cascade through association with the adaptor protein WTIP.
Title: Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP.
WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling.
Title: WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling.
Wtip regulates the stable formation of cell adhesions to both extracellular matrix and neighboring cells and suggest that Wtip is necessary for normal glomerular filtration barrier function
Title: WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-AA025297 (e-PCR)
- UniSTS:3590

RH91502 (e-PCR)
- UniSTS:92000

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA-mediated gene silencing by inhibition of translation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Wilms tumor protein 1-interacting protein

Names: Wilms tumor 1 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080436.2 → NP_001073905.1 Wilms tumor protein 1-interacting protein

See identical proteins and their annotated locations for NP_001073905.1

Status: VALIDATED

Source sequence(s)

AC008747

Consensus CDS

CCDS59375.1

UniProtKB/Swiss-Prot

A6NIX2

Related

ENSP00000466953.2, ENST00000590071.7

Conserved Domains (3) summary

cd09352
Location:225 → 278

LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins

cd09355
Location:290 → 342

LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins

cd09438
Location:350 → 411

LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

34481758..34512304

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011526452.4 → XP_011524754.1 Wilms tumor protein 1-interacting protein isoform X1

Conserved Domains (3) summary

cd09352
Location:225 → 278

LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins

cd09355
Location:290 → 342

LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins

cl02475
Location:350 → 404

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006723014.5 → XP_006723077.1 Wilms tumor protein 1-interacting protein isoform X2

Conserved Domains (3) summary

cd09352
Location:225 → 278

LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins

cd09355
Location:290 → 342

LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins

cl02475
Location:350 → 384

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_011526453.4 → XP_011524755.1 Wilms tumor protein 1-interacting protein isoform X3

Conserved Domains (2) summary

cd09355
Location:49 → 101

LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins

cl02475
Location:1 → 37

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Reference GRCh38.p14 PATCHES

Genomic

NW_025791809.1 Reference GRCh38.p14 PATCHES

Range

146778..177324

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333254.1 → XP_054189229.1 Wilms tumor protein 1-interacting protein isoform X4
XM_054333255.1 → XP_054189230.1 Wilms tumor protein 1-interacting protein isoform X5
XM_054333256.1 → XP_054189231.1 Wilms tumor protein 1-interacting protein isoform X6

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

37026321..37056847

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054319808.1 → XP_054175783.1 Wilms tumor protein 1-interacting protein isoform X1
XM_054319809.1 → XP_054175784.1 Wilms tumor protein 1-interacting protein isoform X2
XM_054319810.1 → XP_054175785.1 Wilms tumor protein 1-interacting protein isoform X3