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    MORN4 MORN repeat containing 4 [ Homo sapiens (human) ]

    Gene ID: 118812, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MORN4provided by HGNC
    Official Full Name
    MORN repeat containing 4provided by HGNC
    Primary source
    HGNC:HGNC:24001
    See related
    Ensembl:ENSG00000171160 MIM:617736; AllianceGenome:HGNC:24001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UTA; rtp; C10orf83; bA548K23.4
    Summary
    Predicted to be involved in response to axon injury. Located in cytoplasm and filopodium tip. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in brain (RPKM 7.3), kidney (RPKM 3.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MORN4 in Genome Data Viewer
    Location:
    10q24.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97614555..97634156, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98494762..98514356, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99374312..99393913, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14301 Neighboring gene ankyrin repeat domain 2 Neighboring gene 4-hydroxy-2-oxoglutarate aldolase 1 Neighboring gene chromosome 10 open reading frame 62 Neighboring gene Sharpr-MPRA regulatory region 10262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99366549-99367050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99367051-99367550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3854 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:99399170-99399353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3856 Neighboring gene phosphatidylinositol 4-kinase type 2 alpha Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:99411103-99412302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99435535-99436034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3857 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:99446822-99448021 Neighboring gene arginine vasopressin induced 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Invertebrate and vertebrate class III myosins interact with MORN repeat-containing adaptor proteins. Mecklenburg KL, et al. PLoS One, 2015. PMID 25822849, Free PMC Article
    2. A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. Bhattacharya MR, et al. J Neurosci, 2012 Apr 11. PMID 22496551, Free PMC Article
    3. Drosophila retinophilin contains MORN repeats and is conserved in humans. Mecklenburg KL. Mol Genet Genomics, 2007 May. PMID 17285308
    4. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
    5. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25925

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to axon injury IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to axon injury ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stereocilium tip ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MORN repeat-containing protein 4
    Names
    44050 protein
    protein 44050
    retinophilin homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098831.2 → NP_001092301.1  MORN repeat-containing protein 4

      See identical proteins and their annotated locations for NP_001092301.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AJ431726
      Consensus CDS
      CCDS7468.1
      UniProtKB/Swiss-Prot
      Q86Y54, Q8NDC4
      UniProtKB/TrEMBL
      A6XB87
      Conserved Domains (1) summary
      PLN03185
      Location:6 → 143
      PLN03185; phosphatidylinositol phosphate kinase; Provisional

    2. NM_178832.4 → NP_849154.1  MORN repeat-containing protein 4

      See identical proteins and their annotated locations for NP_849154.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AJ312050, AL834132
      Consensus CDS
      CCDS7468.1
      UniProtKB/Swiss-Prot
      Q86Y54, Q8NDC4
      UniProtKB/TrEMBL
      A6XB87
      Related
      ENSP00000307636.6, ENST00000307450.11
      Conserved Domains (1) summary
      PLN03185
      Location:6 → 143
      PLN03185; phosphatidylinositol phosphate kinase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      97614555..97634156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539251.4 → XP_011537553.1  MORN repeat-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011537553.1

      UniProtKB/Swiss-Prot
      Q86Y54, Q8NDC4
      UniProtKB/TrEMBL
      A6XB87
      Conserved Domains (1) summary
      PLN03185
      Location:6 → 143
      PLN03185; phosphatidylinositol phosphate kinase; Provisional

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      98494762..98514356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364722.1 → XP_054220697.1  MORN repeat-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q86Y54, Q8NDC4
      UniProtKB/TrEMBL
      A6XB87
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NDC4.1 GenPept UniProtKB/Swiss-Prot:Q8NDC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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