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    Qrich1 glutamine-rich 1 [ Mus musculus (house mouse) ]

    Gene ID: 69232, updated on 9-Dec-2024

    Summary

    Official Symbol
    Qrich1provided by MGI
    Official Full Name
    glutamine-rich 1provided by MGI
    Primary source
    MGI:MGI:1916482
    See related
    Ensembl:ENSMUSG00000006673 AllianceGenome:MGI:1916482
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b2b2404Clo; 2610028H07Rik
    Summary
    Predicted to enable DNA binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within kidney development. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system; facial prominence; female reproductive system; spleen; and urinary system. Orthologous to human QRICH1 (glutamine rich 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 54.1), ovary adult (RPKM 39.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Qrich1 in Genome Data Viewer
    Location:
    9 F2; 9 59.45 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108394010..108437366)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108516982..108560167)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2916 Neighboring gene ubiquitin specific peptidase 19 Neighboring gene STARR-positive B cell enhancer ABC_E3860 Neighboring gene glutaminyl-tRNA synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E3861 Neighboring gene STARR-positive B cell enhancer ABC_E3862 Neighboring gene inosine monophosphate dehydrogenase 2 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in PERK-mediated unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in integrated stress response signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrated stress response signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transcriptional regulator QRICH1
    Names
    glutamine-rich protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114119.1NP_001107591.1  transcriptional regulator QRICH1

      See identical proteins and their annotated locations for NP_001107591.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK151491, BB851544, BF658891, CT010508
      Consensus CDS
      CCDS52927.1
      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Related
      ENSMUSP00000006851.9, ENSMUST00000006851.15
      Conserved Domains (2) summary
      cd01671
      Location:645
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606759
      DUF3504; Domain of unknown function (DUF3504)
    2. NM_175143.5NP_780352.2  transcriptional regulator QRICH1

      See identical proteins and their annotated locations for NP_780352.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK151491, BB851544, BC120916, BF658891
      Consensus CDS
      CCDS52927.1
      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Related
      ENSMUSP00000107782.4, ENSMUST00000112155.9
      Conserved Domains (2) summary
      cd01671
      Location:645
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606759
      DUF3504; Domain of unknown function (DUF3504)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108394010..108437366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511809.4XP_006511872.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511872.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:645
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606759
      DUF3504; Domain of unknown function (DUF3504)
    2. XM_030244560.2XP_030100420.1  transcriptional regulator QRICH1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UA37
      Conserved Domains (1) summary
      pfam12012
      Location:507667
      DUF3504; Domain of unknown function (DUF3504)
    3. XM_006511808.4XP_006511871.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511871.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:645
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606759
      DUF3504; Domain of unknown function (DUF3504)
    4. XM_017313561.3XP_017169050.1  transcriptional regulator QRICH1 isoform X4

      Conserved Domains (2) summary
      pfam12012
      Location:256416
      DUF3504; Domain of unknown function (DUF3504)
      cl14633
      Location:645
      DD; Death Domain Superfamily of protein-protein interaction domains
    5. XM_006511813.4XP_006511876.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511876.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:645
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606759
      DUF3504; Domain of unknown function (DUF3504)
    6. XM_006511812.3XP_006511875.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511875.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:645
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606759
      DUF3504; Domain of unknown function (DUF3504)
    7. XM_006511811.5XP_006511874.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511874.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:645
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606759
      DUF3504; Domain of unknown function (DUF3504)
    8. XM_006511814.3XP_006511877.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511877.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:645
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606759
      DUF3504; Domain of unknown function (DUF3504)
    9. XM_006511818.2XP_006511881.1  transcriptional regulator QRICH1 isoform X4

      See identical proteins and their annotated locations for XP_006511881.1

      Conserved Domains (2) summary
      pfam12012
      Location:256416
      DUF3504; Domain of unknown function (DUF3504)
      cl14633
      Location:645
      DD; Death Domain Superfamily of protein-protein interaction domains
    10. XM_036155242.1XP_036011135.1  transcriptional regulator QRICH1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UA37
      Conserved Domains (1) summary
      pfam12012
      Location:507667
      DUF3504; Domain of unknown function (DUF3504)
    11. XM_006511810.4XP_006511873.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511873.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:645
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606759
      DUF3504; Domain of unknown function (DUF3504)
    12. XM_036155244.1XP_036011137.1  transcriptional regulator QRICH1 isoform X4

      Conserved Domains (2) summary
      pfam12012
      Location:256416
      DUF3504; Domain of unknown function (DUF3504)
      cl14633
      Location:645
      DD; Death Domain Superfamily of protein-protein interaction domains
    13. XM_017313560.3XP_017169049.1  transcriptional regulator QRICH1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UA37
      Conserved Domains (1) summary
      pfam12012
      Location:507667
      DUF3504; Domain of unknown function (DUF3504)
    14. XM_030244561.2XP_030100421.1  transcriptional regulator QRICH1 isoform X4

      Conserved Domains (2) summary
      pfam12012
      Location:256416
      DUF3504; Domain of unknown function (DUF3504)
      cl14633
      Location:645
      DD; Death Domain Superfamily of protein-protein interaction domains
    15. XM_036155243.1XP_036011136.1  transcriptional regulator QRICH1 isoform X3

      UniProtKB/TrEMBL
      Q8BUN3
      Related
      ENSMUSP00000141267.2, ENSMUST00000193258.6
      Conserved Domains (1) summary
      cd01671
      Location:645
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain