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    Usp32 ubiquitin specific peptidase 32 [ Mus musculus (house mouse) ]

    Gene ID: 237898, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp32provided by MGI
    Official Full Name
    ubiquitin specific peptidase 32provided by MGI
    Primary source
    MGI:MGI:2144475
    See related
    Ensembl:ENSMUSG00000000804 AllianceGenome:MGI:2144475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2900074J03Rik; 6430526O11Rik
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in positive regulation of TORC1 signaling. Predicted to be located in cytosol. Predicted to be active in Golgi apparatus. Is expressed in choroid plexus; cranial ganglion; and dorsal root ganglion. Orthologous to human USP32 (ubiquitin specific peptidase 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 14.5), liver E14.5 (RPKM 12.8) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Usp32 in Genome Data Viewer
    Location:
    11 C; 11 51.34 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84875263..85031107, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84984437..85140281, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33028 Neighboring gene predicted gene, 32917 Neighboring gene carbonic anhydrase 4 Neighboring gene STARR-positive B cell enhancer ABC_E5257 Neighboring gene STARR-seq mESC enhancer starr_30231 Neighboring gene STARR-seq mESC enhancer starr_30232 Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial pseudogene Neighboring gene ribosomal protein L13, pseudogene 1 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30233 Neighboring gene STARR-positive B cell enhancer ABC_E7034 Neighboring gene STARR-seq mESC enhancer starr_30234 Neighboring gene CHD1 helical C-terminal domain containing 1 Neighboring gene predicted gene, 23506 Neighboring gene amyloid beta precursor protein binding protein 2 Neighboring gene predicted gene, 51947

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 32
    Names
    deubiquitinating enzyme 32
    ubiquitin specific protease 32
    ubiquitin thioesterase 32
    ubiquitin-specific-processing protease 32
    NP_001025105.1
    XP_011247292.1
    XP_011247293.1
    XP_030101829.1
    XP_030101830.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029934.1NP_001025105.1  ubiquitin carboxyl-terminal hydrolase 32

      See identical proteins and their annotated locations for NP_001025105.1

      Status: VALIDATED

      Source sequence(s)
      AL596183, AL669859, BC058994
      Consensus CDS
      CCDS36264.1
      UniProtKB/Swiss-Prot
      F8VPZ3, Q3US74, Q6PD17, Q7TT84, Q8CCP4
      Related
      ENSMUSP00000103710.3, ENSMUST00000108075.9
      Conserved Domains (6) summary
      COG5560
      Location:5181316
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd00051
      Location:237293
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl02553
      Location:12251565
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:519586
      DUSP; DUSP domain
      pfam13499
      Location:236293
      EF-hand_7; EF-hand domain pair
      pfam14836
      Location:623710
      Ubiquitin_3; Ubiquitin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      84875263..85031107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245970.1XP_030101830.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

      Conserved Domains (3) summary
      COG5126
      Location:148298
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      COG5560
      Location:4771275
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam00443
      Location:11931523
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. XM_011248990.1XP_011247292.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

      Conserved Domains (3) summary
      COG5126
      Location:189339
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      COG5560
      Location:5181330
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam00443
      Location:12481578
      UCH; Ubiquitin carboxyl-terminal hydrolase
    3. XM_030245969.2XP_030101829.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

      Conserved Domains (3) summary
      COG5126
      Location:148298
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      COG5560
      Location:4771289
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam00443
      Location:12071537
      UCH; Ubiquitin carboxyl-terminal hydrolase
    4. XM_011248991.1XP_011247293.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

      Conserved Domains (2) summary
      COG5126
      Location:189339
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      COG5560
      Location:518910
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]