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    Pank1 pantothenate kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 75735, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pank1provided by MGI
    Official Full Name
    pantothenate kinase 1provided by MGI
    Primary source
    MGI:MGI:1922985
    See related
    Ensembl:ENSMUSG00000033610 AllianceGenome:MGI:1922985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pank; Pank1b
    Summary
    Enables pantothenate kinase activity. Involved in coenzyme A biosynthetic process. Located in cell periphery and cytoplasm. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human PANK1 (pantothenate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 4.1), liver adult (RPKM 3.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pank1 in Genome Data Viewer
    Location:
    19 C1; 19 29.79 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34784335..34862420, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34806935..34883423, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 12 Neighboring gene predicted gene, 18425 Neighboring gene STARR-seq mESC enhancer starr_46002 Neighboring gene STARR-seq mESC enhancer starr_46003 Neighboring gene STARR-seq mESC enhancer starr_46004 Neighboring gene predicted gene, 22082 Neighboring gene microRNA 107 Neighboring gene STARR-positive B cell enhancer ABC_E2525 Neighboring gene STARR-seq mESC enhancer starr_46008 Neighboring gene STARR-seq mESC enhancer starr_46009 Neighboring gene STARR-seq mESC enhancer starr_46010 Neighboring gene kinesin family member 20B Neighboring gene microRNA 1950 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Clone Names

    • 4632412I06Rik, 5430426F23Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyl-CoA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pantothenate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pantothenate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pantothenate kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables pantothenate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables pantothenate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pantothenate kinase 1
    Names
    pantothenic acid kinase 1
    NP_001107811.1
    NP_076281.1
    XP_006527490.1
    XP_030106986.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114339.2NP_001107811.1  pantothenate kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_001107811.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as alpha).
      Source sequence(s)
      AC113244, AC125259, AF200357, AK017345
      Consensus CDS
      CCDS50424.1
      UniProtKB/Swiss-Prot
      Q8K4K6, Q9D3K1, Q9QXM8
      Related
      ENSMUSP00000043562.6, ENSMUST00000036584.13
      Conserved Domains (1) summary
      pfam03630
      Location:189537
      Fumble; Fumble
    2. NM_023792.2NP_076281.1  pantothenate kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_076281.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2, also known as beta) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC125259, AF200357
      Consensus CDS
      CCDS37966.1
      UniProtKB/TrEMBL
      Q543J7
      Related
      ENSMUSP00000108079.2, ENSMUST00000112460.3
      Conserved Domains (1) summary
      pfam03630
      Location:14362
      Fumble; Fumble

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      34784335..34862420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527427.5XP_006527490.1  pantothenate kinase 1 isoform X1

      Conserved Domains (2) summary
      PHA03309
      Location:5185
      PHA03309; transcriptional regulator ICP4; Provisional
      pfam03630
      Location:189478
      Fumble
    2. XM_030251126.2XP_030106986.1  pantothenate kinase 1 isoform X2

      Conserved Domains (1) summary
      pfam03630
      Location:14303
      Fumble