CDC37L1 cell division cycle 37 like 1, HSP90 cochaperone [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDC37L1provided by HGNC
Official Full Name: cell division cycle 37 like 1, HSP90 cochaperoneprovided by HGNC
Primary source: HGNC:HGNC:17179
See related: Ensembl:ENSG00000106993 MIM:610346; AllianceGenome:HGNC:17179
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HARC; CDC37B
Summary: CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in liver (RPKM 13.5), heart (RPKM 8.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9p24.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (4679569..4708399)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (4683245..4712075)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (4679569..4708399)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-terminal domain of Harc is a key determinant of its cochaperone functions
Title: Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock.
Harc forms dimers in vitro. The structural similarities between Harc and Cdc37 suggest that Harc may function to regulate the Hsp90-mediated folding of Cdc37-dependent protein kinases into functional conformations via dimerization with Cdc37.
Title: Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AB050415 (e-PCR)
- UniSTS:480147

MARC_7349-7350:992008364:1 (e-PCR)
- UniSTS:231324

MARC_7349-7350:996687799:1 (e-PCR)
- UniSTS:231324

RH15867 (e-PCR)
- UniSTS:22499

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in platelet dense granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: hsp90 co-chaperone Cdc37-like 1

Names: CDC37 cell division cycle 37 homolog-like 1; Hsp90-associating relative of Cdc37; cell division cycle 37 homolog-like 1; cell division cycle 37 like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.