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    LINC00518 long intergenic non-protein coding RNA 518 [ Homo sapiens (human) ]

    Gene ID: 221718, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00518provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 518provided by HGNC
    Primary source
    HGNC:HGNC:28626
    See related
    AllianceGenome:HGNC:28626
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LENOX; C6orf218
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC00518 in Genome Data Viewer
    Location:
    6p24.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (10427785..10434822, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (10295518..10302554, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (10428018..10435055, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene transcription factor AP-2 alpha Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:10403277-10404476 Neighboring gene TFAP2A antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16900 Neighboring gene TFAP2A antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:10414531-10415188 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:10415189-10415848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:10416507-10417164 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:10417165-10417822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:10419141-10419798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16901 Neighboring gene uncharacterized LOC107986564 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:10433906-10435105 Neighboring gene MIR5689 host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:10440968-10441468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:10441469-10441969 Neighboring gene microRNA 5689 Neighboring gene mitochondrial ribosomal protein L48 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00518: a key player in tumor progression and clinical outcomes. Yi Q, et al. Front Immunol, 2024. PMID 39108268, Free PMC Article
    2. Long noncoding RNA LINC00518 induces radioresistance by regulating glycolysis through an miR-33a-3p/HIF-1α negative feedback loop in melanoma. Liu Y, et al. Cell Death Dis, 2021 Mar 4. PMID 33664256, Free PMC Article
    3. LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network. Barbagallo C, et al. Cancers (Basel), 2020 Dec 21. PMID 33371395, Free PMC Article
    4. Development of a novel noninvasive adhesive patch test for the evaluation of pigmented lesions of the skin. Gerami P, et al. J Am Acad Dermatol, 2014 Aug. PMID 24906614
    5. The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma. Gambi G, et al. Cancer Res, 2022 Dec 16. PMID 36214632, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00518: a key player in tumor progression and clinical outcomes.
      Title: LINC00518: a key player in tumor progression and clinical outcomes.
    2. LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network.
      Title: LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network.
    3. The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma.
      Title: The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and Promote Resistance to MAPK Inhibition in Melanoma.
    4. Long noncoding RNA LINC00518 induces radioresistance by regulating glycolysis through an miR-33a-3p/HIF-1alpha negative feedback loop in melanoma.
      Title: Long noncoding RNA LINC00518 induces radioresistance by regulating glycolysis through an miR-33a-3p/HIF-1α negative feedback loop in melanoma.
    5. Long noncoding RNA LINC00518 acts as a competing endogenous RNA to promote the metastasis of malignant melanoma via miR-204-5p/AP1S2 axis.
      Title: Long noncoding RNA LINC00518 acts as a competing endogenous RNA to promote the metastasis of malignant melanoma via miR-204-5p/AP1S2 axis.
    6. Knockdown of long non-coding RNA LINC00518 inhibits cervical cancer proliferation and metastasis by modulating JAK/STAT3 signaling.
      Title: Knockdown of long non-coding RNA LINC00518 inhibits cervical cancer proliferation and metastasis by modulating JAK/STAT3 signaling.
    7. Down-regulation of LINC00518 might have the ability to suppress Breast cancer progression by up-regulating CDX2 expression through the reduction of methylation and blockade of the Wnt signaling pathway, resulting in the inhibition of proliferation and promotion of apoptosis of BC epithelial cells.
      Title: Down-regulated expression of LINC00518 prevents epithelial cell growth and metastasis in breast cancer through the inhibition of CDX2 methylation and the Wnt signaling pathway.
    8. overexpression of Linc00518 contributed to the paclitaxel resistance in prostate cancer via sequestering miR-216b-5p.
      Title: Long non-coding RNA Linc00518 promotes paclitaxel resistance of the human prostate cancer by sequestering miR-216b-5p.
    9. Linc00518 knockdown enhanced chemosensitivity to adriamycin (ADR), vincristine (VCR) and paclitaxel (PTX), and boosted ADR-, VCR- and PTX-induced apoptosis in ADR-resistant MCF-7 cells.
      Title: Linc00518 Contributes to Multidrug Resistance Through Regulating the MiR-199a/MRP1 Axis in Breast Cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • LincRNA-ENhancer of OXidative phosphorylation

    Clone Names

    • MGC40222

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027793.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL138885, BC016666

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      10427785..10434822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      10295518..10302554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152738.1: Suppressed sequence

      Description
      NM_152738.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N0U6.1 GenPept UniProtKB/Swiss-Prot:Q8N0U6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials