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    DND1 DND microRNA-mediated repression inhibitor 1 [ Homo sapiens (human) ]

    Gene ID: 373863, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DND1provided by HGNC
    Official Full Name
    DND microRNA-mediated repression inhibitor 1provided by HGNC
    Primary source
    HGNC:HGNC:23799
    See related
    Ensembl:ENSG00000256453 MIM:609385; AllianceGenome:HGNC:23799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RBMS4
    Summary
    This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in testis (RPKM 7.3), colon (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DND1 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (140670794..140673576, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (141196191..141198973, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (140050379..140053161, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:140026953-140027488 Neighboring gene microRNA 3655 Neighboring gene IK cytokine Neighboring gene uncharacterized LOC124901088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:140043900-140044566 Neighboring gene WD repeat domain 55 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:140052035-140052830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:140052831-140053626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23284 Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23285 Neighboring gene HARS1 and HARS2 bidirectional promoter region Neighboring gene histidyl-tRNA synthetase 2, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells. Zhu R, et al. BMC Mol Biol, 2011 Aug 18. PMID 21851623, Free PMC Article
    2. High DND1 Level Indicates a Poor Prognostic Factor in Prostate Cancer. Xu G, et al. Dis Markers, 2021. PMID 34721738, Free PMC Article
    3. Screening for germline DND1 mutations in testicular cancer patients. Sijmons RH, et al. Fam Cancer, 2010 Sep. PMID 20411342, Free PMC Article
    4. MicroRNA-24 inhibits the proliferation, migration and invasion and enhances chemosensitivity of human gastric cancer by targeting DND1. Jiang W, et al. J BUON, 2020 Mar-Apr. PMID 32521898
    5. Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. Linger R, et al. Genes Chromosomes Cancer, 2008 Mar. PMID 18069663, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA-binding protein DND1 participates in migration, invasion, and EMT of prostate cancer cells by degrading CLIC4.
      Title: RNA-binding protein DND1 participates in migration, invasion, and EMT of prostate cancer cells by degrading CLIC4.
    2. Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1.
      Title: Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1.
    3. A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
      Title: A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
    4. High DND1 Level Indicates a Poor Prognostic Factor in Prostate Cancer.
      Title: High DND1 Level Indicates a Poor Prognostic Factor in Prostate Cancer.
    5. Human DND1-RRM2 forms a non-canonical domain swapped dimer.
      Title: Human DND1-RRM2 forms a non-canonical domain swapped dimer.
    6. MicroRNA-24 inhibits the proliferation, migration and invasion and enhances chemosensitivity of human gastric cancer by targeting DND1.
      Title: MicroRNA-24 inhibits the proliferation, migration and invasion and enhances chemosensitivity of human gastric cancer by targeting DND1.
    7. Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention.
      Title: RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells.
    8. Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR.
      Title: RNA-Binding Protein Dnd1 Promotes Breast Cancer Apoptosis by Stabilizing the Bim mRNA in a miR-221 Binding Site.
    9. RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation
      Title: The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation.
    10. APOBEC3G inhibits DND1 function to regulate microRNA activity.
      Title: APOBEC3 inhibits DEAD-END function to regulate microRNA activity.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC34750

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of miRNA-mediated gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of miRNA-mediated gene silencing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dead end protein homolog 1
    Names
    RNA-binding motif, single-stranded-interacting protein 4
    dead end homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194249.3 → NP_919225.1  dead end protein homolog 1

      See identical proteins and their annotated locations for NP_919225.1

      Status: REVIEWED

      Source sequence(s)
      AC116353, BC033496
      Consensus CDS
      CCDS4236.1
      UniProtKB/Swiss-Prot
      Q8IYX4
      Related
      ENSP00000445366.1, ENST00000542735.2
      Conserved Domains (2) summary
      pfam14709
      Location:253 → 333
      DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1
      cl25617
      Location:18 → 219
      LSM_int_assoc; LSM-interacting associated unstructured

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      140670794..140673576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      141196191..141198973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IYX4.1 GenPept UniProtKB/Swiss-Prot:Q8IYX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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