Sost sclerostin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sostprovided by MGI
Official Full Name: sclerostinprovided by MGI
Primary source: MGI:MGI:1921749
See related: Ensembl:ENSMUSG00000001494 AllianceGenome:MGI:1921749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5430411E23Rik
Summary: Predicted to enable several functions, including BMP binding activity; DNA-binding transcription factor binding activity; and carbohydrate binding activity. Acts upstream of or within negative regulation of ossification; negative regulation of signal transduction; and ossification. Predicted to be located in Golgi apparatus. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Is expressed in several structures, including arterial system; jaw; limb bud; nervous system; and skeleton. Used to study SOST-related sclerosing bone dysplasia and sclerosteosis 1. Human ortholog(s) of this gene implicated in autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in genital fat pad adult (RPKM 4.4), testis adult (RPKM 2.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 65.48 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101853284..101857841, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101962458..101967015, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation.
Title: PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation.
Mef2c regulates bone mass through Sost-dependent and -independent mechanisms.
Title: Mef2c regulates bone mass through Sost-dependent and -independent mechanisms.
Sclerostin deficiency effectively promotes bone morphogenetic protein-2-induced ectopic bone formation.
Title: Sclerostin deficiency effectively promotes bone morphogenetic protein-2-induced ectopic bone formation.
Sclerostin blockade promotes bone metastases of Wnt-responsive breast cancer cells.
Title: Sclerostin blockade promotes bone metastases of Wnt-responsive breast cancer cells.
Sostdc1 Suppression in the Absence of Sclerostin Potentiates Anabolic Action of Cortical Bone in Mice.
Title: Sostdc1 Suppression in the Absence of Sclerostin Potentiates Anabolic Action of Cortical Bone in Mice.
SOST gene suppression stimulates osteocyte Wnt/beta-catenin signaling to prevent bone resorption and attenuates particle-induced osteolysis.
Title: SOST gene suppression stimulates osteocyte Wnt/β-catenin signaling to prevent bone resorption and attenuates particle-induced osteolysis.
Sclerostin Influences Exercise-Induced Adaptations in Body Composition and White Adipose Tissue Morphology in Male Mice.
Title: Sclerostin Influences Exercise-Induced Adaptations in Body Composition and White Adipose Tissue Morphology in Male Mice.
Sclerostin aggravates insulin signaling in skeletal muscle and hepatic steatosis via upregulation of ER stress by mTOR-mediated inhibition of autophagy under hyperlipidemic conditions.
Title: Sclerostin aggravates insulin signaling in skeletal muscle and hepatic steatosis via upregulation of ER stress by mTOR-mediated inhibition of autophagy under hyperlipidemic conditions.
Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes.
Title: Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes.
Suppression of Sost/Sclerostin and Dickkopf-1 Augment Intervertebral Disc Structure in Mice.
Title: Suppression of Sost/Sclerostin and Dickkopf-1 Augment Intervertebral Disc Structure in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (139)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (10)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to parathyroid hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to parathyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in ossification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sclerostin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024449.6 → NP_077769.4 sclerostin precursor

See identical proteins and their annotated locations for NP_077769.4

Status: VALIDATED

Source sequence(s)

AK017295, AK041382, BY593587

Consensus CDS

CCDS25481.1

UniProtKB/Swiss-Prot

B2RQA5, Q99P68, Q9D3L7

Related

ENSMUSP00000001534.7, ENSMUST00000001534.7

Conserved Domains (1) summary

cl21545
Location:1 → 208

GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

101853284..101857841 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534376.4 → XP_006534439.1 sclerostin isoform X1

Conserved Domains (1) summary

cl21545
Location:14 → 153

GHB_like; Glycoprotein hormone beta chain homologues