Il2ra interleukin 2 receptor, alpha chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il2raprovided by MGI
Official Full Name: interleukin 2 receptor, alpha chainprovided by MGI
Primary source: MGI:MGI:96549
See related: Ensembl:ENSMUSG00000026770 AllianceGenome:MGI:96549
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD25; Il2r; Ly-43
Summary: Enables interleukin-2 binding activity and interleukin-2 receptor activity. Acts upstream of or within several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Located in external side of plasma membrane. Is expressed in bone marrow and yolk sac. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 5.6), mammary gland adult (RPKM 1.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 8.91 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (11647603..11698005)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (11642792..11693194)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-2Ralpha KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Ralpha in lymphoid and non-lymphoid cells.
Title: IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells.
Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption.
Title: Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption.
Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.
Title: Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.
The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo.
Title: The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo.
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25.
Title: Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25.
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
Title: Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells.
Title: Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells.
T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Ralpha-KO autoimmune mice.
Title: T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.
CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation.
Title: CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation.
high-affinity T cells sustained IL-2R expression longer and expressed two novel Th cell differentiation regulators, Eef1e1 and Gbp2, to a higher level than low-affinity T cells.
Title: TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.

Submit: New GeneRIF Correction See all GeneRIFs (114)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Spontaneous (1) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Il2ra (e-PCR), detects polymorphism
- UniSTS:259181

PMC126074P1 (e-PCR)
- UniSTS:270526

PMC126074P2 (e-PCR)
- UniSTS:270527

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables interleukin-2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-2 binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-2 receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to interleukin-2 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-2 receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within activation-induced cell death of T cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in interleukin-2-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of lymphocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell homeostatic proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of T cell tolerance induction	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell tolerance induction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-2 receptor subunit alpha

Names: IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha chain; IL-2R subunit alpha; IL2-RA; p55 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008367.3 → NP_032393.3 interleukin-2 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_032393.3

Status: VALIDATED

Source sequence(s)

AK037369, AL831794, BY200401

Consensus CDS

CCDS15685.1

UniProtKB/Swiss-Prot

P01590, Q61731

UniProtKB/TrEMBL

Q544I2, Q8C2H9

Related

ENSMUSP00000028111.5, ENSMUST00000028111.6

Conserved Domains (1) summary

cd00033
Location:121 → 181

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system