Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gdpd1provided by MGI
Official Full Name: glycerophosphodiester phosphodiesterase domain containing 1provided by MGI
Primary source: MGI:MGI:1913819
See related: Ensembl:ENSMUSG00000061666 AllianceGenome:MGI:1913819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610020H15Rik
Summary: Enables lysophospholipase activity and phosphoric diester hydrolase activity. Acts upstream of or within N-acylethanolamine metabolic process and phospholipid metabolic process. Located in membrane and perinuclear region of cytoplasm. Is expressed in several structures, including adrenal medulla; alimentary system; nervous system; sensory organ; and urinary system. Orthologous to human GDPD1 (glycerophosphodiester phosphodiesterase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 61.4), testis adult (RPKM 41.0) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.87 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (86924620..86964963, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (87033794..87074137, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of recombinant murine GDE4 and GDE7, enzymes producing lysophosphatidic acid and/or cyclic phosphatidic acid.
Title: Characterization of recombinant murine GDE4 and GDE7, enzymes producing lysophosphatidic acid and/or cyclic phosphatidic acid.
GDE4 may act as lysophospholipase D, which is involved in the generation of N-acylethanolamines and lysophhosphatidic acid.
Title: Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a possible involvement in bioactive N-acylethanolamine biosynthesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Dcr15 (e-PCR), detects polymorphism
- UniSTS:507458

D11Mit325 (e-PCR), detects polymorphism
- UniSTS:126539

AW742735 (e-PCR)
- UniSTS:208723

NoName (e-PCR)
- UniSTS:236688

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lysophospholipase activity	EXP Inferred from Experiment more info	PubMed
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoric diester hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoric diester hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoric diester hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-acylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within N-acylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in N-acylethanolamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within N-acylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in N-acylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lysophospholipase D GDPD1

Names: glycerophosphodiester phosphodiesterase 4; glycerophosphodiester phosphodiesterase domain-containing protein 1

NP_079914.1

EC 3.1.4.39

XP_036012792.1

EC 3.1.4.39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025638.2 → NP_079914.1 lysophospholipase D GDPD1

See identical proteins and their annotated locations for NP_079914.1

Status: VALIDATED

Source sequence(s)

AK013864, AK039183, BY282485, BY697784, CA451251

Consensus CDS

CCDS25206.1

UniProtKB/Swiss-Prot

Q9CRY7, Q9CT14, Q9D4X7

Related

ENSMUSP00000020804.8, ENSMUST00000020804.8

Conserved Domains (1) summary

cd08612
Location:14 → 311

GDPD_GDE4; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE4 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

86924620..86964963 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156899.1 → XP_036012792.1 lysophospholipase D GDPD1 isoform X1

Conserved Domains (1) summary

cd08612
Location:1 → 242

GDPD_GDE4; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE4 and similar proteins