Carlr cardiac and apoptosis-related long non-coding RNA [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Carlrprovided by MGI
Official Full Name: cardiac and apoptosis-related long non-coding RNAprovided by MGI
Primary source: MGI:MGI:1914024
See related: Ensembl:ENSMUSG00000097638 AllianceGenome:MGI:1914024
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Carl; 4933439G12Rik
Summary: Enables pre-miRNA binding activity. Acts upstream of or within several processes, including cellular response to anoxia; negative regulation of mitochondrial fission; and regulation of miRNA-mediated gene silencing. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 2; 2 A3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (18804056..18806629, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (18799245..18801818, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CARL can suppress mitochondrial fission and apoptosis by targeting miR-539 and PHB2.
Title: CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables pre-miRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to anoxia	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of miRNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of miRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.