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    Cylc1 cylicin, basic protein of sperm head cytoskeleton 1 [ Mus musculus (house mouse) ]

    Gene ID: 67407, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cylc1provided by MGI
    Official Full Name
    cylicin, basic protein of sperm head cytoskeleton 1provided by MGI
    Primary source
    MGI:MGI:1914657
    See related
    Ensembl:ENSMUSG00000073001 AllianceGenome:MGI:1914657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930401M13Rik
    Summary
    Acts upstream of or within maintenance of cell number; single fertilization; and spermatogenesis. Predicted to be active in acrosomal matrix. Used to study male infertility. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 8. Orthologous to human CYLC1 (cylicin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 1.2) See more
    Orthologs
    human all
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    Genomic context

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    See Cylc1 in Genome Data Viewer
    Location:
    X E1; X 48.2 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (110154024..110169624)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (111110418..111125854)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 26108 Neighboring gene STARR-seq mESC enhancer starr_47766 Neighboring gene POU domain, class 3, transcription factor 4 Neighboring gene STARR-seq mESC enhancer starr_47767 Neighboring gene STARR-seq mESC enhancer starr_47768 Neighboring gene STARR-seq mESC enhancer starr_47769 Neighboring gene STARR-seq mESC enhancer starr_47770 Neighboring gene STARR-seq mESC enhancer starr_47771 Neighboring gene developmental pluripotency associated 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47772 Neighboring gene nuclear encoded tRNA arginine 4 (anticodon CCT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human. Schneider S, et al. Elife, 2023 Nov 28. PMID 38013430, Free PMC Article
    2. Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice. Jin HJ, et al. Elife, 2024 Apr 4. PMID 38573307, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice.
      Title: Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within acrosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular component organization or biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of cell number IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in acrosomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in perinuclear theca IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cylicin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026134.3 → NP_080410.3  cylicin-1

      Status: VALIDATED

      Source sequence(s)
      LO016976
      Consensus CDS
      CCDS41103.2
      UniProtKB/TrEMBL
      A0A1B0GR13
      Related
      ENSMUSP00000147334.2, ENSMUST00000210720.3
      Conserved Domains (1) summary
      pfam15241
      Location:26 → 131
      Cylicin_N; Cylicin N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      110154024..110169624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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