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    RPC34 DNA-directed RNA polymerase III subunit C34 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPC34
    Official Full Name
    DNA-directed RNA polymerase III subunit C34
    Primary source
    SGD:S000005286
    Locus tag
    YNR003C
    See related
    AllianceGenome:SGD:S000005286; FungiDB:YNR003C; VEuPathDB:YNR003C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III. Located in mitochondrion. Part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human POLR3F (RNA polymerase III subunit F). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPC34 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (634344..635297, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene putative ammonium permease ATO2 Neighboring gene Swm2p Neighboring gene ESCRT-0 subunit protein VPS27

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An essential and specific subunit of RNA polymerase III (C) is encoded by gene RPC34 in Saccharomyces cerevisiae. Stettler S, et al. J Biol Chem, 1992 Oct 25. PMID 1400451
    2. RNA polymerase III interferes with Ty3 integration. Connolly CM, et al. FEBS Lett, 1997 Apr 1. PMID 9108309
    3. Dual role of the C34 subunit of RNA polymerase III in transcription initiation. Brun I, et al. EMBO J, 1997 Sep 15. PMID 9312031, Free PMC Article
    4. Twelve open reading frames revealed in the 23.6 kb segment flanking the centromere on the Saccharomyces cerevisiae chromosome XIV right arm. Verhasselt P, et al. Yeast, 1994 Oct. PMID 7900425
    5. Interaction between a complex of RNA polymerase III subunits and the 70-kDa component of transcription factor IIIB. Werner M, et al. J Biol Chem, 1993 Oct 5. PMID 8407894

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase III complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in mitochondrion IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit C34
    NP_014400.1
    • RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      634344..635297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183180.1 → NP_014400.1  TPA: DNA-directed RNA polymerase III subunit C34 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014400.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1H9, P32910
      UniProtKB/TrEMBL
      A6ZS78, B3LPN6, B5VR36, C7GLQ1, C8ZFM9, G2WL61, N1NY47
      Conserved Domains (1) summary
      COG5111
      Location:4 → 317
      RPC34; DNA-directed RNA polymerase III, subunit C34 [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32910.1

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