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    DLG2 discs large MAGUK scaffold protein 2 [ Homo sapiens (human) ]

    Gene ID: 1740, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DLG2provided by HGNC
    Official Full Name
    discs large MAGUK scaffold protein 2provided by HGNC
    Primary source
    HGNC:HGNC:2901
    See related
    Ensembl:ENSG00000150672 MIM:603583; AllianceGenome:HGNC:2901
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSD93; PSD-93; PPP1R58; chapsyn-110
    Summary
    This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
    Expression
    Biased expression in brain (RPKM 9.7), adrenal (RPKM 2.3) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DLG2 in Genome Data Viewer
    Location:
    11q14.1
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (83455012..85628373, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (83391509..85565050, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (83166055..85339417, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369420 Neighboring gene CCDC90B antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:83036792-83037292 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:83149453-83149953 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:83152064-83152757 Neighboring gene CYCS pseudogene 28 Neighboring gene uncharacterized LOC107984425 Neighboring gene DLG2 intron CAGE-defined low expression enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:83298443-83299026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:83299027-83299610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5354 Neighboring gene DLG2 antisense RNA 2 Neighboring gene suppressor of cytokine signaling 6 pseudogene Neighboring gene uncharacterized LOC124902729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5355 Neighboring gene lactate dehydrogenase A like 6D, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:83769989-83771188 Neighboring gene NANOG hESC enhancer GRCh37_chr11:83868528-83869174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5357 Neighboring gene uncharacterized LOC105369416 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 72 Neighboring gene NANOG hESC enhancer GRCh37_chr11:84384719-84385229 Neighboring gene uncharacterized LOC124902727 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:84505287-84505788 Neighboring gene ribosomal protein L9 pseudogene 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5359 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5360 Neighboring gene REST corepressor 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:85059939-85060760 Neighboring gene DExH-box helicase 9 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:85181858-85182577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:85183649-85184545 Neighboring gene Sharpr-MPRA regulatory region 9338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:85250835-85251373 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:85248765-85249264 Neighboring gene RNA, U6 small nuclear 1292, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:85317081-85318280 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:85319023-85319982 Neighboring gene MPRA-validated peak1373 silencer Neighboring gene MPRA-validated peak1374 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:85338434-85338942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5367 Neighboring gene transmembrane protein 126B Neighboring gene transmembrane protein 126A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evaluation of DLG2 as a positional candidate for disposition index in African-Americans from the IRAS Family Study. Palmer ND, et al. Diabetes Res Clin Pract, 2010 Jan. PMID 19931931, Free PMC Article
    2. DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population. Wu HC, et al. Neurobiol Aging, 2018 Apr. PMID 29290481
    3. Strong association of de novo copy number mutations with sporadic schizophrenia. Xu B, et al. Nat Genet, 2008 Jul. PMID 18511947
    4. Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium. Godreau D, et al. Cardiovasc Res, 2002 Dec. PMID 12445884
    5. Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia. Toyooka K, et al. J Neurochem, 2002 Nov. PMID 12421351

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glioma stem cell-derived exosomes induce the transformation of astrocytes via the miR-3065-5p/DLG2 signaling axis.
      Title: Glioma stem cell-derived exosomes induce the transformation of astrocytes via the miR-3065-5p/DLG2 signaling axis.
    2. DLG2 intragenic exonic deletions reinforce the link to neurodevelopmental disorders and suggest a potential association with congenital anomalies and dysmorphism.
      Title: DLG2 intragenic exonic deletions reinforce the link to neurodevelopmental disorders and suggest a potential association with congenital anomalies and dysmorphism.
    3. Enhancing DLG2 Implications in Neuropsychiatric Disorders: Analysis of a Cohort of Eight Patients with 11q14.1 Imbalances.
      Title: Enhancing DLG2 Implications in Neuropsychiatric Disorders: Analysis of a Cohort of Eight Patients with 11q14.1 Imbalances.
    4. Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.
      Title: Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.
    5. DLG2 impairs dsDNA break repair and maintains genome integrity in neuroblastoma.
      Title: DLG2 impairs dsDNA break repair and maintains genome integrity in neuroblastoma.
    6. DLG2 Mutations in the Etiology of Pubertal Delay and Idiopathic Hypogonadotropic Hypogonadism.
      Title: DLG2 Mutations in the Etiology of Pubertal Delay and Idiopathic Hypogonadotropic Hypogonadism.
    7. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.
      Title: Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.
    8. Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival.
      Title: Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival.
    9. SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.
      Title: SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.
    10. DLG2 variants in patients with pubertal disorders.
      Title: DLG2 variants in patients with pubertal disorders.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-11-28)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2018-11-28)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    A genome-wide association study identifies susceptibility loci for Wilms tumor.
    EBI GWAS Catalog
    A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.
    EBI GWAS Catalog
    Genome wide association scan for chronic periodontitis implicates novel locus.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
    EBI GWAS Catalog
    Genome-wide association with bone mass and geometry in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data.
    EBI GWAS Catalog
    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37266, MGC131811, DKFZp781D1854, DKFZp781E0954

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanylate kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ionotropic glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anterograde axonal protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to potassium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde axonal protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in juxtaparanode region of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    disks large homolog 2
    Names
    channel-associated protein of synapse-110
    channel-associated protein of synapses, 110kDa
    discs, large homolog 2, chapsyn-110
    postsynaptic density protein PSD-93
    protein phosphatase 1, regulatory subunit 58

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021375.2 RefSeqGene

      Range
      6192..2178363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142699.3 → NP_001136171.1  disks large homolog 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC023118, AP000639, AP000642, AP000773, AP001791, AP002370, AP002751, AP002797, AP002803, AP002878, AP003026, AP003093, AP003305
      Consensus CDS
      CCDS44690.1
      UniProtKB/TrEMBL
      A0A3B3ITF1
      Related
      ENSP00000365272.2, ENST00000376104.7
      Conserved Domains (7) summary
      cd12032
      Location:639 → 712
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      smart00072
      Location:795 → 962
      GuKc; Guanylate kinase homologues
      cd00992
      Location:524 → 602
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:784 → 962
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:383 → 450
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:120 → 202
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cl02672
      Location:1 → 25
      L27; L27 domain

    2. NM_001142700.2 → NP_001136172.1  disks large homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001136172.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses a distinct 5' UTR and coding region, lacks three coding exons, and includes an alternate coding exon, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK126776, AP003026, BM678399
      Consensus CDS
      CCDS44691.1
      UniProtKB/TrEMBL
      F8VYC1
      Related
      ENSP00000402275.2, ENST00000418306.6
      Conserved Domains (5) summary
      cd12032
      Location:431 → 504
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      smart00072
      Location:569 → 736
      GuKc; Guanylate kinase homologues
      cd00992
      Location:316 → 394
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:558 → 736
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:227 → 290
      PDZ_assoc; PDZ-associated domain of NMDA receptors

    3. NM_001142702.2 → NP_001136174.1  disks large homolog 2 isoform 4

      See identical proteins and their annotated locations for NP_001136174.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, and uses an alternate splice pattern in the central coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus and differs at an internal segment, compared to isoform 1.
      Source sequence(s)
      AP000773, AP002370, AP003026
      Consensus CDS
      CCDS44692.1
      UniProtKB/Swiss-Prot
      Q15700
      Related
      ENSP00000393049.2, ENST00000426717.6
      Conserved Domains (2) summary
      pfam00625
      Location:143 → 321
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    4. NM_001206769.2 → NP_001193698.1  disks large homolog 2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. Isoform 5 has a distinct N-terminus and is compared to isoform 1.
      Source sequence(s)
      AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
      Consensus CDS
      CCDS55782.1
      UniProtKB/TrEMBL
      B7Z264
      Related
      ENSP00000280241.8, ENST00000280241.12
      Conserved Domains (6) summary
      cd12032
      Location:573 → 646
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      smart00072
      Location:729 → 896
      GuKc; Guanylate kinase homologues
      cd00992
      Location:458 → 536
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:718 → 896
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:317 → 384
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 136
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    5. NM_001300983.1 → NP_001287912.1  disks large homolog 2 isoform 6

      See identical proteins and their annotated locations for NP_001287912.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (6) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK295094, AP003026
      Consensus CDS
      CCDS73357.1
      UniProtKB/TrEMBL
      B7Z264, B7Z2T4
      Related
      ENSP00000435849.1, ENST00000532653.5
      Conserved Domains (6) summary
      cd12032
      Location:534 → 607
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      smart00072
      Location:672 → 839
      GuKc; Guanylate kinase homologues
      cd00992
      Location:419 → 497
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:661 → 839
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:278 → 345
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:14 → 97
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    6. NM_001351274.2 → NP_001338203.1  disks large homolog 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000642, AP000773, AP001791, AP002370, AP002751, AP002797, AP002803, AP002878, AP003026, AP003093, AP003305
      Consensus CDS
      CCDS91566.1
      UniProtKB/TrEMBL
      A0A3B3ITF1, A0A994J819
      Related
      ENSP00000516284.1, ENST00000706226.1
      Conserved Domains (6) summary
      cd12032
      Location:651 → 724
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:536 → 614
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:778 → 956
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:4 → 62
      L27_1; L27_1
      pfam10600
      Location:395 → 462
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:132 → 214
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    7. NM_001351275.2 → NP_001338204.1  disks large homolog 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000642, AP000773, AP001791, AP002370, AP002751, AP002797, AP002803, AP002878, AP003026, AP003093, AP003305
      Consensus CDS
      CCDS91565.1
      UniProtKB/TrEMBL
      A0A3B3ITF1, A0A994J7P1
      Related
      ENSP00000516288.1, ENST00000706233.1
      Conserved Domains (6) summary
      cd12032
      Location:650 → 723
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:535 → 613
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:777 → 955
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:4 → 62
      L27_1; L27_1
      pfam10600
      Location:394 → 461
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:132 → 213
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    8. NM_001351276.2 → NP_001338205.1  disks large homolog 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP001791, AP001825, AP002370, AP002751, AP002797, AP003026, AP003305
      UniProtKB/TrEMBL
      B7Z264
      Conserved Domains (5) summary
      cd12032
      Location:553 → 626
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:438 → 516
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:680 → 858
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:297 → 364
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:34 → 116
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    9. NM_001364.3 → NP_001355.2  disks large homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001355.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a distinct 5' UTR and coding region, compared to variant 1. The resulting isoform (2), also known as alpha, has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB209252, AP003026, BM678399, CR749820, DA778233
      Consensus CDS
      CCDS41696.1
      UniProtKB/Swiss-Prot
      B7WNY8, F8W9V6, Q15700, Q59G57, Q5H9Q4, Q68CQ8, Q6ZTA8
      UniProtKB/TrEMBL
      B7Z264
      Related
      ENSP00000381355.2, ENST00000398309.6
      Conserved Domains (6) summary
      cd12032
      Location:534 → 607
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      smart00072
      Location:690 → 857
      GuKc; Guanylate kinase homologues
      cd00992
      Location:419 → 497
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:679 → 857
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:278 → 345
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:14 → 97
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    10. NM_001377966.1 → NP_001364895.1  disks large homolog 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
      UniProtKB/TrEMBL
      B7Z264
      Conserved Domains (5) summary
      cd12032
      Location:573 → 646
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:458 → 536
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:718 → 890
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:317 → 384
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 136
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    11. NM_001377967.1 → NP_001364896.1  disks large homolog 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
      Consensus CDS
      CCDS91558.1
      UniProtKB/TrEMBL
      A0A994J822, B7Z264
      Related
      ENSP00000516291.1, ENST00000706243.1
      Conserved Domains (5) summary
      cd12032
      Location:573 → 646
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:458 → 536
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:700 → 878
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:317 → 384
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 136
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    12. NM_001377968.1 → NP_001364897.1  disks large homolog 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP000857, AP001791, AP002370, AP002751, AP002797, AP003026, AP003305
      Consensus CDS
      CCDS91563.1
      UniProtKB/TrEMBL
      B7Z264, E9PN83
      Related
      ENSP00000432894.1, ENST00000524982.5
      Conserved Domains (5) summary
      cd12032
      Location:534 → 607
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:419 → 497
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:675 → 853
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:278 → 345
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:14 → 97
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    13. NM_001377970.1 → NP_001364899.1  disks large homolog 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
      Consensus CDS
      CCDS91557.1
      UniProtKB/TrEMBL
      A0A994J5T6, B7Z264
      Related
      ENSP00000516282.1, ENST00000706204.1
      Conserved Domains (5) summary
      cd12032
      Location:521 → 594
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:406 → 484
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:666 → 844
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:317 → 380
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 136
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    14. NM_001377971.1 → NP_001364900.1  disks large homolog 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
      UniProtKB/TrEMBL
      B7Z264
      Conserved Domains (5) summary
      cd12032
      Location:521 → 594
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:406 → 484
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:648 → 826
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:317 → 380
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 136
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    15. NM_001377972.1 → NP_001364901.1  disks large homolog 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
      UniProtKB/TrEMBL
      F8VYC1
      Related
      ENSP00000381353.4, ENST00000330014.11
      Conserved Domains (5) summary
      cd12032
      Location:501 → 574
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:386 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:628 → 806
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:245 → 312
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:36 → 64
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    16. NM_001377973.1 → NP_001364902.1  disks large homolog 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP001791, AP002370, AP002751, AP002797, AP003026, AP003305
      Consensus CDS
      CCDS91559.1
      UniProtKB/TrEMBL
      A0A5F9ZH92, B7Z264
      Related
      ENSP00000500169.2, ENST00000527466.2
      Conserved Domains (5) summary
      cd12032
      Location:492 → 565
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:377 → 455
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:619 → 797
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:236 → 303
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:24 → 55
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    17. NM_001377974.1 → NP_001364903.1  disks large homolog 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
      UniProtKB/TrEMBL
      F8VYC1
      Conserved Domains (5) summary
      cd12032
      Location:449 → 522
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:334 → 412
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:576 → 754
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:245 → 308
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:36 → 64
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    18. NM_001377975.1 → NP_001364904.1  disks large homolog 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP002370, AP002751, AP002797, AP003305
      Consensus CDS
      CCDS91556.1
      UniProtKB/TrEMBL
      A0A994J570, A0A994J7N9
      Related
      ENSP00000516287.1, ENST00000706232.1
      Conserved Domains (3) summary
      cd00992
      Location:386 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam10600
      Location:245 → 312
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:36 → 64
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    19. NM_001377976.1 → NP_001364905.1  disks large homolog 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AP000773, AP002370, AP003026
      Conserved Domains (2) summary
      pfam00625
      Location:172 → 350
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:45 → 118
      SH3; Src Homology 3 domain superfamily

    20. NM_001377977.1 → NP_001364906.1  disks large homolog 2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AP000773, AP002370, AP003026
      Conserved Domains (2) summary
      pfam00625
      Location:170 → 348
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:43 → 116
      SH3; Src Homology 3 domain superfamily

    21. NM_001377978.1 → NP_001364907.1  disks large homolog 2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AP000773, AP002370, AP003026
      Conserved Domains (2) summary
      pfam00625
      Location:161 → 339
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    22. NM_001377979.1 → NP_001364908.1  disks large homolog 2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AP000773, AP002370, AP003026
      Consensus CDS
      CCDS91555.1
      UniProtKB/TrEMBL
      B5MCC5, B7Z640
      Related
      ENSP00000385113.3, ENST00000404783.7
      Conserved Domains (2) summary
      pfam00625
      Location:157 → 335
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    23. NM_001377980.1 → NP_001364909.1  disks large homolog 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AP000773, AP002370, AP003026
      Conserved Domains (2) summary
      pfam00625
      Location:143 → 315
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    24. NM_001377981.1 → NP_001364910.1  disks large homolog 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AP000773, AP002370, AP003026
      Conserved Domains (2) summary
      pfam00625
      Location:126 → 304
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    25. NM_001377982.1 → NP_001364911.1  disks large homolog 2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AP000773, AP002370, AP003026
      Conserved Domains (1) summary
      pfam00625
      Location:84 → 262
      Guanylate_kin; Guanylate kinase

    26. NM_001377983.1 → NP_001364912.1  disks large homolog 2 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP002797, AP003305
      Conserved Domains (2) summary
      cd00992
      Location:137 → 221
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam10608
      Location:45 → 136
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RNA

    1. NR_165353.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
      Related
      ENST00000706203.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      83455012..85628373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017256.3 → XP_016872745.1  disks large homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITF1

    2. XM_047426494.1 → XP_047282450.1  disks large homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITF1

    3. XM_017017257.3 → XP_016872746.1  disks large homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A3B3ITF1

    4. XM_047426498.1 → XP_047282454.1  disks large homolog 2 isoform X8

      UniProtKB/TrEMBL
      A0A3B3ITF1

    5. XM_047426496.1 → XP_047282452.1  disks large homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A3B3ITF1

    6. XM_047426495.1 → XP_047282451.1  disks large homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A3B3ITF1

    7. XM_047426499.1 → XP_047282455.1  disks large homolog 2 isoform X9

      UniProtKB/TrEMBL
      A0A3B3ITF1

    8. XM_047426497.1 → XP_047282453.1  disks large homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A3B3ITF1

    9. XM_017017255.3 → XP_016872744.1  disks large homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITF1

    10. XM_017017258.2 → XP_016872747.1  disks large homolog 2 isoform X7

      UniProtKB/TrEMBL
      A0A3B3ITF1

    11. XM_017017285.2 → XP_016872774.1  disks large homolog 2 isoform X31

      UniProtKB/TrEMBL
      B7Z264

    12. XM_017017276.2 → XP_016872765.1  disks large homolog 2 isoform X22

      UniProtKB/TrEMBL
      B7Z264

    13. XM_017017269.2 → XP_016872758.1  disks large homolog 2 isoform X18

      UniProtKB/TrEMBL
      B7Z264

    14. XM_017017280.3 → XP_016872769.1  disks large homolog 2 isoform X29

      UniProtKB/TrEMBL
      B7Z264

    15. XM_017017279.2 → XP_016872768.1  disks large homolog 2 isoform X27

      UniProtKB/TrEMBL
      B7Z264, E9PIJ9
      Related
      ENSP00000435809.2, ENST00000527088.2

    16. XM_017017270.2 → XP_016872759.1  disks large homolog 2 isoform X19

      UniProtKB/TrEMBL
      B7Z264

    17. XM_011544782.3 → XP_011543084.1  disks large homolog 2 isoform X14

      UniProtKB/TrEMBL
      A0A3B3ITF1
      Conserved Domains (6) summary
      cd12032
      Location:555 → 628
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      smart00072
      Location:711 → 878
      GuKc; Guanylate kinase homologues
      cd00992
      Location:440 → 518
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:700 → 878
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:299 → 366
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:36 → 118
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    18. XM_017017263.2 → XP_016872752.1  disks large homolog 2 isoform X11

      UniProtKB/TrEMBL
      A0A3B3ITF1

    19. XM_017017268.2 → XP_016872757.1  disks large homolog 2 isoform X17

      UniProtKB/TrEMBL
      B7Z264

    20. XM_017017267.2 → XP_016872756.1  disks large homolog 2 isoform X16

      UniProtKB/TrEMBL
      B7Z264
      Conserved Domains (6) summary
      cd12032
      Location:534 → 607
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      smart00072
      Location:704 → 871
      GuKc; Guanylate kinase homologues
      cd00992
      Location:419 → 497
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:693 → 871
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:278 → 345
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:14 → 97
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    21. XM_017017265.3 → XP_016872754.1  disks large homolog 2 isoform X13

      UniProtKB/TrEMBL
      B7Z264
      Conserved Domains (3) summary
      cd12032
      Location:553 → 626
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      smart00072
      Location:723 → 890
      GuKc; Guanylate kinase homologues
      cd00992
      Location:438 → 516
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    22. XM_017017281.3 → XP_016872770.1  disks large homolog 2 isoform X28

      UniProtKB/TrEMBL
      A0A994J587, B7Z264
      Related
      ENSP00000516312.1, ENST00000706266.1

    23. XM_047426502.1 → XP_047282458.1  disks large homolog 2 isoform X24

      UniProtKB/TrEMBL
      B7Z264

    24. XM_017017271.3 → XP_016872760.1  disks large homolog 2 isoform X20

      UniProtKB/TrEMBL
      A0A994J7Q5, B7Z264
      Related
      ENSP00000516313.1, ENST00000706267.1

    25. XM_047426500.1 → XP_047282456.1  disks large homolog 2 isoform X15

      UniProtKB/TrEMBL
      A0A3B3ISW2, B7Z264
      Related
      ENSP00000497475.1, ENST00000648622.1

    26. XM_017017264.3 → XP_016872753.1  disks large homolog 2 isoform X12

      UniProtKB/TrEMBL
      B7Z264

    27. XM_047426505.1 → XP_047282461.1  disks large homolog 2 isoform X32

      UniProtKB/TrEMBL
      B7Z264

    28. XM_047426503.1 → XP_047282459.1  disks large homolog 2 isoform X26

      UniProtKB/TrEMBL
      B7Z264

    29. XM_017017277.2 → XP_016872766.1  disks large homolog 2 isoform X23

      UniProtKB/TrEMBL
      B7Z264

    30. XM_017017273.3 → XP_016872762.1  disks large homolog 2 isoform X21

      UniProtKB/TrEMBL
      B7Z264

    31. XM_017017262.2 → XP_016872751.1  disks large homolog 2 isoform X10

      UniProtKB/TrEMBL
      B7Z264

    32. XM_005273810.5 → XP_005273867.1  disks large homolog 2 isoform X25

      UniProtKB/TrEMBL
      E9PIW2
      Related
      ENSP00000433848.1, ENST00000531015.5
      Conserved Domains (6) summary
      cd12032
      Location:501 → 574
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      smart00072
      Location:657 → 824
      GuKc; Guanylate kinase homologues
      cd00992
      Location:386 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:646 → 824
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:245 → 312
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:36 → 64
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    33. XM_017017284.2 → XP_016872773.1  disks large homolog 2 isoform X30

      UniProtKB/TrEMBL
      B7Z264

    34. XM_017017287.2 → XP_016872776.1  disks large homolog 2 isoform X34

    35. XM_017017289.2 → XP_016872778.1  disks large homolog 2 isoform X35

      Conserved Domains (2) summary
      pfam00625
      Location:202 → 380
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:43 → 116
      SH3; Src Homology 3 domain superfamily

    36. XM_017017290.2 → XP_016872779.1  disks large homolog 2 isoform X36

      Conserved Domains (2) summary
      pfam00625
      Location:175 → 353
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    37. XM_047426506.1 → XP_047282462.1  disks large homolog 2 isoform X33

      UniProtKB/TrEMBL
      A0A994J7N9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      83391509..85565050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367893.1 → XP_054223868.1  disks large homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITF1

    2. XM_054367891.1 → XP_054223866.1  disks large homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A3B3ITF1

    3. XM_054367895.1 → XP_054223870.1  disks large homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A3B3ITF1

    4. XM_054367899.1 → XP_054223874.1  disks large homolog 2 isoform X8

      UniProtKB/TrEMBL
      A0A3B3ITF1

    5. XM_054367896.1 → XP_054223871.1  disks large homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A3B3ITF1

    6. XM_054367894.1 → XP_054223869.1  disks large homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A3B3ITF1

    7. XM_054367900.1 → XP_054223875.1  disks large homolog 2 isoform X9

      UniProtKB/TrEMBL
      A0A3B3ITF1

    8. XM_054367897.1 → XP_054223872.1  disks large homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A3B3ITF1

    9. XM_054367892.1 → XP_054223867.1  disks large homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A3B3ITF1

    10. XM_054367898.1 → XP_054223873.1  disks large homolog 2 isoform X7

      UniProtKB/TrEMBL
      A0A3B3ITF1

    11. XM_054367920.1 → XP_054223895.1  disks large homolog 2 isoform X29

      UniProtKB/TrEMBL
      B7Z264

    12. XM_054367918.1 → XP_054223893.1  disks large homolog 2 isoform X27

      UniProtKB/TrEMBL
      B7Z264, E9PIJ9

    13. XM_054367902.1 → XP_054223877.1  disks large homolog 2 isoform X11

      UniProtKB/TrEMBL
      A0A3B3ITF1

    14. XM_054367922.1 → XP_054223897.1  disks large homolog 2 isoform X31

      UniProtKB/TrEMBL
      B7Z264

    15. XM_054367909.1 → XP_054223884.1  disks large homolog 2 isoform X18

      UniProtKB/TrEMBL
      B7Z264

    16. XM_054367910.1 → XP_054223885.1  disks large homolog 2 isoform X19

      UniProtKB/TrEMBL
      B7Z264

    17. XM_054367905.1 → XP_054223880.1  disks large homolog 2 isoform X14

      UniProtKB/TrEMBL
      A0A3B3ITF1

    18. XM_054367913.1 → XP_054223888.1  disks large homolog 2 isoform X22

      UniProtKB/TrEMBL
      B7Z264

    19. XM_054367908.1 → XP_054223883.1  disks large homolog 2 isoform X17

      UniProtKB/TrEMBL
      B7Z264

    20. XM_054367907.1 → XP_054223882.1  disks large homolog 2 isoform X16

      UniProtKB/TrEMBL
      B7Z264

    21. XM_054367904.1 → XP_054223879.1  disks large homolog 2 isoform X13

      UniProtKB/TrEMBL
      B7Z264

    22. XM_054367919.1 → XP_054223894.1  disks large homolog 2 isoform X28

      UniProtKB/TrEMBL
      A0A994J587, B7Z264

    23. XM_054367915.1 → XP_054223890.1  disks large homolog 2 isoform X24

      UniProtKB/TrEMBL
      B7Z264

    24. XM_054367911.1 → XP_054223886.1  disks large homolog 2 isoform X20

      UniProtKB/TrEMBL
      A0A994J7Q5, B7Z264

    25. XM_054367906.1 → XP_054223881.1  disks large homolog 2 isoform X15

      UniProtKB/TrEMBL
      A0A3B3ISW2, B7Z264

    26. XM_054367903.1 → XP_054223878.1  disks large homolog 2 isoform X12

      UniProtKB/TrEMBL
      B7Z264

    27. XM_054367923.1 → XP_054223898.1  disks large homolog 2 isoform X32

      UniProtKB/TrEMBL
      B7Z264

    28. XM_054367917.1 → XP_054223892.1  disks large homolog 2 isoform X26

      UniProtKB/TrEMBL
      B7Z264

    29. XM_054367914.1 → XP_054223889.1  disks large homolog 2 isoform X23

      UniProtKB/TrEMBL
      B7Z264

    30. XM_054367912.1 → XP_054223887.1  disks large homolog 2 isoform X21

      UniProtKB/TrEMBL
      B7Z264

    31. XM_054367901.1 → XP_054223876.1  disks large homolog 2 isoform X10

      UniProtKB/TrEMBL
      B7Z264

    32. XM_054367916.1 → XP_054223891.1  disks large homolog 2 isoform X25

      UniProtKB/TrEMBL
      E9PIW2

    33. XM_054367921.1 → XP_054223896.1  disks large homolog 2 isoform X30

      UniProtKB/TrEMBL
      B7Z264

    34. XM_054367924.1 → XP_054223899.1  disks large homolog 2 isoform X37

      UniProtKB/TrEMBL
      B7Z264

    35. XM_054367926.1 → XP_054223901.1  disks large homolog 2 isoform X34

    36. XM_054367927.1 → XP_054223902.1  disks large homolog 2 isoform X35

    37. XM_054367925.1 → XP_054223900.1  disks large homolog 2 isoform X33

      UniProtKB/TrEMBL
      A0A994J7N9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175892.3: Suppressed sequence

      Description
      NM_175892.3: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15700.3 GenPept UniProtKB/Swiss-Prot:Q15700

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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