stg string [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: stgprovided by FlyBase
Official Full Name: stringprovided by FlyBase
Primary source: FLYBASE:FBgn0003525
Locus tag: Dmel_CG1395
See related: AllianceGenome:FB:FBgn0003525
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0224/06; 0245/03; 0439/22; 0730/13; 0896/05; 0967/05; 0980/06; 1083/13; 1089/08; 1143/02; 5473; anon-EST:Liang-2.21; cdc25; Cdc25; CDC25; cdc25/string; Cdc25c; Cdc25[stg]; Cdc25[Stg]; cdc25[string]; Cdc25[string]; Cdc25[String]; CDC25[string]; CG1395; clone 2.21; Dmel\CG1395; EP1213; l(3)01235; l(3)j10B9; l(3)j1D3; l(3)j1E3; l(3)j3D1; l(3)s2213; S(rux)3A; st; Stg; STG; Stg/Cdc25; stg[cdc25]; str/cdc25; String/Cdc25; SY3-4
Summary: Enables protein tyrosine phosphatase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; centriole replication; and negative regulation of cell size. Located in chromosome and nucleus. Is expressed in several structures, including epithelium; ganglia; germ layer; mitotic domain; and stem cell. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; endometrial cancer; prostate cancer; and urinary bladder cancer. Orthologous to several human genes including CDC25A (cell division cycle 25A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 99A5-99A5; 3-98 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29251826..29255800, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25077548..25081522, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we show that during the development of epithelial cells in the imaginal discs, the G2/M transition, and hence cell proliferation, is controlled by Emc via Da. In eukaryotic cells, the main activator of this transition is the Cdc25 phosphatase, string
Title: The bHLH factors extramacrochaetae and daughterless control cell cycle in Drosophila imaginal discs through the transcriptional regulation of the Cdc25 phosphatase string.
The degradation rate of String protein gradually increases during the late syncytial cycles in a manner dependent on the nuclear-to-cytoplasmic ratio and on the DNA replication checkpoints.
Title: Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program.
Premature removal of cdc25 transcripts by RNAi did not affect progression to the midblastula transition.
Title: Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling.
findings suggest that high Cdc25 and Cdk1 contribute to the speed of the rapid, pre-midblastula transition (MBT) S phases and that down-regulation of these activities plays a broader role in MBT-associated changes than was previously suspected
Title: Embryonic onset of late replication requires Cdc25 down-regulation.
String (Cdc25) regulates stem cell maintenance, proliferation and aging in Drosophila testis.
Title: String (Cdc25) regulates stem cell maintenance, proliferation and aging in Drosophila testis.
SIN3 and STG are linked in a genetic pathway that affects cell cycle progression in a developing tissue
Title: Regulation of cell proliferation and wing development by Drosophila SIN3 and String.
Thereby, we show that abdominal histoblasts, which grow while in G2 arrest during larval stages, enter a proliferative stage in the pupal period that is initiated by ecdysone-dependent string/Cdc25 phosphatase transcription.
Title: Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts.
double-stranded RNA-mediated depletion of dPrp38 or dMFAP1 causes cells to arrest in G(2)/M, and this is paralleled by a reduction in mRNA levels of the mitotic phosphatase string/cdc25.
Title: Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression.
String and dappled were identified as being important for the proper formation of adult external sensory (ES) organs.
Title: A mis-expression study of factors affecting Drosophila PNS cell identity.
EYA and SO may influence cell proliferation through transcriptional regulation of stg.
Title: Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm0380 (e-PCR)
- UniSTS:48452

Dm0309 (e-PCR)
- UniSTS:13978

Dm0321 (e-PCR)
- UniSTS:4574

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histoblast morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: string

Names: CG1395-PA; CG1395-PB; Cdc25; String/Cdc25 phosphatase; cdc25/string; stg-PA; stg-PB; string/cdc25; suppressor of rux 3A

NP_001263066.1

EC 3.1.3.48

NP_524547.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

29251826..29255800 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079823.4 → NP_524547.1 string, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524547.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P20483, Q9VAL9

UniProtKB/TrEMBL

A0A0B4KI54

Related

FBpp0084766

Conserved Domains (1) summary

cd01530
Location:297 → 425

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
NM_001276137.1 → NP_001263066.1 string, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263066.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P20483, Q9VAL9

UniProtKB/TrEMBL

A0A0B4KI54

Conserved Domains (1) summary

cd01530
Location:297 → 425

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...