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    CG8399 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36768, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8399provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034067
    Locus tag
    Dmel_CG8399
    See related
    AllianceGenome:FB:FBgn0034067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:ParkEST009; Dmel\CG8399; sdr2; SDR2
    Summary
    Enables transmembrane ascorbate ferrireductase activity. Involved in intracellular iron ion homeostasis. Located in membrane. Is expressed in adult head. Orthologous to human FRRS1 (ferric chelate reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8399 in Genome Data Viewer
    Location:
    52D14-52D14; 2-76 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16017737..16024627)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11905242..11912132)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Proteasome beta1 subunit Neighboring gene Rrp42 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene caspar Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. How are cytochrome b561 electron currents controlled by membrane voltage and substrate availability? Picco C, et al. Antioxid Redox Signal, 2014 Jul 20. PMID 24410448
    2. DOMON: an ancient extracellular domain in dopamine beta-monooxygenase and other proteins. Aravind L. Trends Biochem Sci, 2001 Sep. PMID 11551777
    3. Comparison of insect and human cytochrome b561 proteins: Insights into candidate ferric reductases in insects. Holst JD, et al. PLoS One, 2023. PMID 38039324, Free PMC Article
    4. Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. Vargas JD, et al. Biochim Biophys Acta, 2003 Sep 23. PMID 14499595
    5. Caspar, a suppressor of antibacterial immunity in Drosophila. Kim M, et al. Proc Natl Acad Sci U S A, 2006 Oct 31. PMID 17050695, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on metal ions IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane ascorbate ferrireductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane ascorbate ferrireductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8399-PA
    CG8399-PB
    stromal cell-derived receptor 2
    NP_001286472.1
    NP_611079.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16017737..16024627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299543.1 → NP_001286472.1  uncharacterized protein Dmel_CG8399, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286472.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGL5
      Conserved Domains (3) summary
      cd08760
      Location:358 → 553
      Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
      cd09628
      Location:223 → 392
      DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
      pfam02014
      Location:40 → 170
      Reeler; Reeler domain

    2. NM_137235.3 → NP_611079.2  uncharacterized protein Dmel_CG8399, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611079.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSU3, Q9V7I1
      Related
      FBpp0086349
      Conserved Domains (3) summary
      cd08760
      Location:358 → 553
      Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
      cd09628
      Location:223 → 392
      DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
      pfam02014
      Location:40 → 170
      Reeler; Reeler domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGL5 A0A0B4LGL5
    Q8MSU3.1 Q8MSU3

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