Cyfip Cytoplasmic FMR1 interacting protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cyfipprovided by FlyBase
Official Full Name: Cytoplasmic FMR1 interacting proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0038320
Locus tag: Dmel_CG4931
See related: AllianceGenome:FB:FBgn0038320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4931; cyfip; CYFIP; CYFIP1; CYFIP1/2; dCyfip; dCYFIP; dCYFIP1; Dmel\CG4931; dSra; DSra-1; PIR121; PIR121/Sra-1; Sra; sra-1; Sra-1; Sra-1/CYFIP; sra1; Sra1; Sra1/PIR121
Summary: Predicted to enable RNA 7-methylguanosine cap binding activity. Involved in several processes, including cell adhesion mediated by integrin; centripetally migrating follicle cell migration; and positive regulation of filopodium assembly. Located in apical part of cell and cytoplasm. Part of SCAR complex. Is expressed in several structures, including adult head; embryonic/larval gut; embryonic/larval neuromuscular junction; ganglia; and tract. Used to study chromosome 15q11.2 deletion syndrome. Human ortholog(s) of this gene implicated in autism spectrum disorder; developmental and epileptic encephalopathy 65; and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1) and CYFIP2 (cytoplasmic FMR1 interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88F1-88F1; 3-57 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15333266..15338365)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11158988..11164087)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The study examined aspects of sensory and cognitive function in flies harboring a mutation in Cyfip, the homologue of one of the genes within the deletion.
Title: Domain-Specific Cognitive Impairments in Humans and Flies With Reduced CYFIP1 Dosage.
These results illustrate a new model to explain the cellular roles of FMRP and CYFIP1 and the molecular significance of their interaction.
Title: New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes.
We propose that Cyfip regulates synapse development and endocytosis by inhibiting actin assembly.
Title: Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly.
Mutations in WAVE/SCAR and in ARP2/3 complex subunits but not in WASP, another major regulator of Actin nucleation, phenocopy CYFIP defects. Thus, the CYFIP-SCAR-ARP2/3 pathway orchestrates specific tissue remodeling processes
Title: CYFIP dependent actin remodeling controls specific aspects of Drosophila eye morphogenesis.
Sra-1 function is mediated through kette. These stabilize each other and directly control the regulation of the cytoskeleton.
Title: Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila.
CYFIP specifically expressed in the nervous system; mutations affect axons and synapses, much like mutations in dFMR1 and Rho GTPase dRac1; CYFIP acts as a dRac1 effector that antagonizes FMR1 function
Title: CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centripetally migrating follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: cytoplasmic FMR1 interacting protein

Names: CG4931-PA; Cyfip-PA; specifically Rac1-associated protein 1; specifically, Rac-1 associated protein 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

15333266..15338365

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142190.3 → NP_650447.1 cytoplasmic FMR1 interacting protein [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650447.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NP16, Q8MR06, Q9VF87

UniProtKB/TrEMBL

U3PXB4

Related

FBpp0082541

Conserved Domains (2) summary

pfam05994
Location:386 → 1244

FragX_IP; Cytoplasmic Fragile-X interacting family

pfam07159
Location:89 → 267

DUF1394; Protein of unknown function (DUF1394)