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    Oscillin oscillin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oscillinprovided by FlyBase
    Official Full Name
    oscillinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031717
    Locus tag
    Dmel_CG6957
    See related
    AllianceGenome:FB:FBgn0031717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6957; Dmel\CG6957
    Summary
    Predicted to enable glucosamine-6-phosphate deaminase activity and identical protein binding activity. Predicted to be involved in several processes, including N-acetylneuraminate catabolic process; UDP-N-acetylglucosamine biosynthetic process; and glucosamine-containing compound catabolic process. Predicted to be active in cytoplasm. Is expressed in adult head; anterior endoderm; anterior endoderm anlage; head mesoderm; and yolk nucleus. Orthologous to several human genes including GNPDA1 (glucosamine-6-phosphate deaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oscillin in Genome Data Viewer
    Location:
    25E6-25E6; 2-17 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5547086..5549614)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5547086..5549614)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Helicase at 25E Neighboring gene Lamin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution, structure, and expression of GNPI/Oscillin orthologous genes. Nakamura Y, et al. Genomics, 2000 Sep 1. PMID 10964516
    2. Precise mapping of one classic and three novel GluRIIA mutants in Drosophila melanogaster. Mallik B, et al. MicroPubl Biol, 2023. PMID 37334199, Free PMC Article
    3. Flanking genes of an essential gene give information about the evolution of metazoa. Zimek A, et al. Eur J Cell Biol, 2011 Apr. PMID 21163549
    4. Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis. Miller M, et al. PLoS Genet, 2017 Jul. PMID 28742844, Free PMC Article
    5. What model organisms and interactomics can reveal about the genetics of human obesity. Williams MJ, et al. Cell Mol Life Sci, 2012 Nov. PMID 22618246, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glucosamine-6-phosphate deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosamine-6-phosphate deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucosamine-6-phosphate deaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylglucosamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in N-acetylneuraminate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in generation of precursor metabolites and energy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucosamine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    oscillin
    Names
    CG6957-PA
    CG6957-PB
    CG6957-PC
    CG6957-PD
    CG6957-PE
    CG6957-PF
    CG6957-PG
    CG6957-PH
    Oscillin-PA
    Oscillin-PB
    Oscillin-PC
    Oscillin-PD
    Oscillin-PE
    Oscillin-PF
    Oscillin-PG
    Oscillin-PH
    NP_001245894.1
    NP_001245895.1
    NP_001245896.1
    NP_001245897.1
    NP_001245898.1
    NP_001260101.1
    NP_608938.1
    NP_723092.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5547086..5549614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258965.2 → NP_001245894.1  oscillin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245894.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMP9
      UniProtKB/TrEMBL
      M9NE92
      Conserved Domains (1) summary
      cl00339
      Location:1 → 253
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    2. NM_001273172.1 → NP_001260101.1  oscillin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260101.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMP9
      UniProtKB/TrEMBL
      M9NE92
      Conserved Domains (1) summary
      cl00339
      Location:1 → 253
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    3. NM_135094.2 → NP_608938.1  oscillin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608938.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMP9
      UniProtKB/TrEMBL
      M9NE92
      Related
      FBpp0078734, FBtr0079101
      Conserved Domains (1) summary
      cl00339
      Location:1 → 253
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    4. NM_001258966.1 → NP_001245895.1  oscillin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND31
      Conserved Domains (1) summary
      cl00339
      Location:1 → 253
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    5. NM_001258968.1 → NP_001245897.1  oscillin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMP9
      UniProtKB/TrEMBL
      M9NE92
      Conserved Domains (1) summary
      cl00339
      Location:1 → 253
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    6. NM_001258967.2 → NP_001245896.1  oscillin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NCR7
      Conserved Domains (1) summary
      cl00339
      Location:1 → 253
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    7. NM_164649.2 → NP_723092.1  oscillin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMP9
      UniProtKB/TrEMBL
      M9NE92
      Related
      FBpp0078735
      Conserved Domains (1) summary
      cl00339
      Location:1 → 253
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    8. NM_001258969.2 → NP_001245898.1  oscillin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND31
      Conserved Domains (1) summary
      cl00339
      Location:1 → 253
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NCR7 M9NCR7
    M9ND31 M9ND31
    M9NE92 M9NE92
    Q9VMP9.1 Q9VMP9

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