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    Cubn Cubilin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cubnprovided by FlyBase
    Official Full Name
    Cubilinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052702
    Locus tag
    Dmel_CG32702
    See related
    AllianceGenome:FB:FBgn0052702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2996; CG32702; CT7882; cubilin; dCubn; Dmel\CG32702; tok-like
    Summary
    Enables cargo receptor activity. Involved in clathrin-dependent endocytosis; nephrocyte filtration; and renal protein absorption. Part of receptor complex. Is expressed in adult head; adult heart; embryonic/larval garland cell; larval pericardial cell; and spermatozoon. Used to study kidney disease. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CUBN (cubilin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Cubn in Genome Data Viewer
    Location:
    8E7-8E10; 1-28 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9558665..9571308, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9452698..9465341, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42767 Neighboring gene Ribosomal protein S28b Neighboring gene uncharacterized protein Neighboring gene Lysophosphatidylcholine acyltransferase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45540

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cubilin and amnionless mediate protein reabsorption in Drosophila nephrocytes. Zhang F, et al. J Am Soc Nephrol, 2013 Feb. PMID 23264686, Free PMC Article
    2. dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity. Feng X, et al. Dis Model Mech, 2021 Sep 1. PMID 34437681, Free PMC Article
    3. A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter. Tao Y, et al. PLoS Biol, 2007 Nov 6. PMID 17988173, Free PMC Article
    4. Proliferation and dissemination of killer meiotic drive loci. Lai EC, et al. Curr Opin Genet Dev, 2023 Oct. PMID 37625205, Free PMC Article
    5. An evolutionary expressed sequence tag analysis of Drosophila spermatheca genes. Prokupek A, et al. Evolution, 2008 Nov. PMID 18752616

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cargo receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cargo receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nephrocyte filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in renal protein absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of receptor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cubilin
    Names
    CG32702-PB
    Cubn-PB
    TMPRSS6 iron sensing
    cubilin ortholog
    dCubilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9558665..9571308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167193.2 → NP_727348.2  cubilin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727348.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T4G4, Q9W332
      Conserved Domains (6) summary
      smart00179
      Location:282 → 322
      EGF_CA; Calcium-binding EGF-like domain
      cd00041
      Location:1100 → 1211
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00054
      Location:192 → 233
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:430 → 457
      EGF; EGF-like domain
      pfam12947
      Location:328 → 366
      EGF_3; EGF domain
      cl00049
      Location:744 → 849
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W332.3 Q9W332

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