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    peg pegasus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pegprovided by FlyBase
    Official Full Name
    pegasusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0046763
    Locus tag
    Dmel_CG17278
    See related
    AllianceGenome:FB:FBgn0046763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD04019; CG17278; Dmel\CG17278
    Summary
    Enables Wnt-protein binding activity. Involved in establishment of protein localization to extracellular region; imaginal disc-derived wing margin morphogenesis; and positive regulation of canonical Wnt signaling pathway. Is active in extracellular space. Is expressed in presumptive capitellum; wing disc; and wing pouch. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See peg in Genome Data Viewer
    Location:
    93B4-93B4; 3-70 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21021044..21024163, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16846766..16849885, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ral interacting protein Neighboring gene Dynein heavy chain at 93AB Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A single cell RNA sequence atlas of the early Drosophila larval eye. Raja KKB, et al. BMC Genomics, 2024 Jun 19. PMID 38890587, Free PMC Article
    2. Pegasus, a small extracellular peptide enhancing short-range diffusion of Wingless. Magny EG, et al. Nat Commun, 2021 Sep 27. PMID 34580289, Free PMC Article
    3. Gene Expression as a Dosimeter in Irradiated Drosophila melanogaster. Shrestha S, et al. J Comput Biol, 2017 Dec. PMID 29035581, Free PMC Article
    4. Evolutionary origin of a novel gene expression pattern through co-option of the latent activities of existing regulatory sequences. Rebeiz M, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21593416, Free PMC Article
    5. Functional analysis of genes differentially expressed in the Drosophila wing disc: role of transcripts enriched in the wing region. Jacobsen TL, et al. Genetics, 2006 Dec. PMID 17028348, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pegasus, a small extracellular peptide enhancing short-range diffusion of Wingless.
      Title: Pegasus, a small extracellular peptide enhancing short-range diffusion of Wingless.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Wnt-protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of protein localization to extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pegasus
    Names
    CG17278-PA
    peg-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21021044..21024163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143973.3 → NP_652230.1  pegasus [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652230.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95SW1, Q9VDG1
      Related
      FBpp0083449
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDG1 Q9VDG1

    Gene LinkOut

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