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    Mec2 Mec2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mec2provided by FlyBase
    Official Full Name
    Mec2provided by FlyBase
    Primary source
    FLYBASE:FBgn0030993
    Locus tag
    Dmel_CG7635
    See related
    AllianceGenome:FB:FBgn0030993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7635; DMec2; Dmel\CG7635; mec-2; mec2
    Summary
    Involved in imaginal disc fusion, thorax closure and nephrocyte filtration. Predicted to be located in nephrocyte diaphragm. Predicted to be active in plasma membrane. Is expressed in adult head and adult heart. Used to study kidney disease. Orthologous to human STOM (stomatin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mec2 in Genome Data Viewer
    Location:
    18A6-18A6; 1-62 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19188035..19190193)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19082068..19084226)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heterochromatin Protein 1D3 chromoshadow domain Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis. Koehler S, et al. J Am Soc Nephrol, 2020 Mar. PMID 32047005, Free PMC Article
    2. Using Drosophila nephrocytes in genetic kidney disease. Helmstädter M, et al. Cell Tissue Res, 2017 Jul. PMID 28401308
    3. Modeling Renal Disease "On the Fly". Millet-Boureima C, et al. Biomed Res Int, 2018. PMID 29955604, Free PMC Article
    4. An in vivo functional analysis system for renal gene discovery in Drosophila pericardial nephrocytes. Zhang F, et al. J Am Soc Nephrol, 2013 Feb. PMID 23291470, Free PMC Article
    5. The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm. Weavers H, et al. Nature, 2009 Jan 15. PMID 18971929, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in imaginal disc fusion, thorax closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nephrocyte filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nephrocyte diaphragm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mec2
    Names
    CG7635-PA
    Mec2-PA
    dPodocin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19188035..19190193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133129.2 → NP_573357.1  Mec2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWL0
      Related
      FBpp0074440, FBtr0074669
      Conserved Domains (2) summary
      smart00244
      Location:88 → 238
      PHB; prohibitin homologues
      cl19107
      Location:107 → 314
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWL0 Q9VWL0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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