Hel25E Helicase at 25E [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hel25Eprovided by FlyBase
Official Full Name: Helicase at 25Eprovided by FlyBase
Primary source: FLYBASE:FBgn0014189
Locus tag: Dmel_CG7269
See related: AllianceGenome:FB:FBgn0014189
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7269; Dbp25F; dHel25E; Dmel\CG7269; DmRH4; hel; Hel; HEL; hel25E; HEL25E; jf26; l(2)25Eb; l(2)gdh-12; l(2)gdh12; l(2)jf26; l(2)k11511; sz; uap56; Uap56; UAP56; Wm6; WM6
Summary: Enables piRNA binding activity. Involved in chromatin remodeling; mRNA export from nucleus; and regulation of gene expression. Located in nucleus. Is active in P granule. Colocalizes with polytene chromosome. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval salivary gland; and ganglia. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human DDX39A (DExD-box helicase 39A) and DDX39B (DExD-box helicase 39B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 25E6-25E6; 2-17 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5539326..5542314, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5539326..5542314, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2alpha.
Title: Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α.
Study presents evidence that UAP56 and Vas are cluster transcript binding proteins that organize a piRNA-processing compartment that spans the nuclear envelope.
Title: UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery.
UAP56 RNA helicase is required for axis specification and cytoplasmic mRNA localization.
Title: UAP56 RNA helicase is required for axis specification and cytoplasmic mRNA localization in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0092 (e-PCR)
- UniSTS:17157

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables piRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of piRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IC Inferred by Curator more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of transcription export complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: helicase at 25E

Names: CG7269-PA; CG7269-PB; CG7269-PC; CG7269-PD; Hel25E-PA; Hel25E-PB; Hel25E-PC; Hel25E-PD; RNA helicase; helicase; lethal(2)25Eb

NP_001260100.1

EC 3.6.4.13

NP_723089.1

EC 3.6.4.13

NP_723090.1

EC 3.6.4.13

NP_723091.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5539326..5542314 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164648.2 → NP_723091.1 helicase at 25E, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723091.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27268, Q540X0, Q9VMQ1

Related

FBpp0078754

Conserved Domains (2) summary

cd18787
Location:259 → 388

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

cd17950
Location:40 → 248

DEADc_DDX39; DEAD-box helicase domain of DEAD box protein 39
NM_164647.1 → NP_723090.1 helicase at 25E, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723090.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27268, Q540X0, Q9VMQ1

Related

FBpp0078756, FBtr0079125

Conserved Domains (2) summary

cd18787
Location:259 → 388

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

cd17950
Location:40 → 248

DEADc_DDX39; DEAD-box helicase domain of DEAD box protein 39
NM_001273171.1 → NP_001260100.1 helicase at 25E, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260100.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PC90

Conserved Domains (2) summary

smart00487
Location:56 → 243

DEXDc; DEAD-like helicases superfamily

cd00268
Location:43 → 242

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_164646.3 → NP_723089.1 helicase at 25E, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723089.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27268, Q540X0, Q9VMQ1

Related

FBpp0078755

Conserved Domains (2) summary

cd18787
Location:259 → 388

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

cd17950
Location:40 → 248

DEADc_DDX39; DEAD-box helicase domain of DEAD box protein 39