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    Orc4 Origin recognition complex subunit 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Orc4provided by FlyBase
    Official Full Name
    Origin recognition complex subunit 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0023181
    Locus tag
    Dmel_CG2917
    See related
    AllianceGenome:FB:FBgn0023181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2917; Dmel\CG2917; dmOrc4; DmORC4; ORC; orc4; ORC4; rDmORC
    Summary
    Enables ribonucleoprotein complex binding activity. Involved in DNA replication initiation. Located in nucleus. Part of nuclear origin of replication recognition complex and nuclear pore. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; ganglia; larval nervous system; and lateral cord. Used to study Meier-Gorlin syndrome 2. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Orc4 in Genome Data Viewer
    Location:
    60E1-60E2; 2-107 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24795740..24797414, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20683263..20684937, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rhythmically expressed gene 5 Neighboring gene antisense RNA:CR43257 Neighboring gene Ecdysis triggering hormone Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue-Specific DNA Replication Defects in Drosophila melanogaster Caused by a Meier-Gorlin Syndrome Mutation in Orc4. McDaniel SL, et al. Genetics, 2020 Feb. PMID 31818869, Free PMC Article
    2. Deletion of the ecdysis-triggering hormone gene leads to lethal ecdysis deficiency. Park Y, et al. Development, 2002 Jan. PMID 11807040
    3. Molecular cloning and biological activity of ecdysis-triggering hormones in Drosophila melanogaster. Park Y, et al. FEBS Lett, 1999 Dec 10. PMID 10601653
    4. Forced binding of the origin of replication complex to chromosomal sites in Drosophila S2 cells creates an origin of replication. Crevel G, et al. J Cell Sci, 2012 Feb 15. PMID 22421364
    5. Functional analysis of mutant and wild-type Drosophila origin recognition complex. Chesnokov I, et al. Proc Natl Acad Sci U S A, 2001 Oct 9. PMID 11593009, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction of the Drosophila ENY2 protein with the ORC complex subunits was investigated. It is found that ORC4 and ORC6 subunits directly interact with ENY2.
      Title: Identification of the ORC Complex Subunits That Can Interact with the ENY2 Protein of Drosophila melanogaster.
    2. Spotted-dick is a zinc-finger protein of Drosophila required for expression of Orc4 and S phase
      Title: Spotted-dick, a zinc-finger protein of Drosophila required for expression of Orc4 and S phase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of origin recognition complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 4
    Names
    CG2917-PA
    Orc4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24795740..24797414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057972.4 → NP_477320.1  origin recognition complex subunit 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W102, Q9Y1B3
      Related
      FBpp0072330
      Conserved Domains (2) summary
      COG1474
      Location:47 → 208
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:257 → 440
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W102 Q9W102
    Q9Y1B3 Q9Y1B3

    Gene LinkOut

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