Hr3 Hormone receptor 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hr3provided by FlyBase
Official Full Name: Hormone receptor 3provided by FlyBase
Primary source: FLYBASE:FBgn0000448
Locus tag: Dmel_CG33183
See related: AllianceGenome:FB:FBgn0000448
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 12.6; 2.4; CG11823; CG12208; CG33183; D; dhr3; dHR3; Dhr3; DHR3; Dmel\CG33183; DmHr3; DmRORalpha; HR3; hr46; Hr46; l(2)46CFi; l(2)k09242; NR1F4
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in compound eye photoreceptor fate commitment; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gut section; ring gland; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 15 and immunodeficiency 42. Orthologous to human RORA (RAR related orphan receptor A); RORB (RAR related orphan receptor B); and RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 46F5-46F7; 2-62 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10203995..10237348, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (6091500..6124853, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nuclear receptor Hr46/Hr3 is required in the blood brain barrier of mature males for courtship.
Title: The nuclear receptor Hr46/Hr3 is required in the blood brain barrier of mature males for courtship.
DHR3 and Hr4 gene expression is dose dependent, is completely controlled by the hormone titer and decreases within hours of 20-hydroxyecdysone withdrawal.
Title: Early-late genes of the ecdysone cascade as models for transcriptional studies.
DHR3 and betaFTZ-F1 activate the EDG84A gene in a redundant manner. The temporal expression of the EDG84A gene is mainly controlled by betaFTZ-F1 but that the binding of DHR3 is also important.
Title: The binding of multiple nuclear receptors to a single regulatory region is important for the proper expression of EDG84A in Drosophila melanogaster.
SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex during development and have multiple common targets across the genome.
Title: [SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation].
DHR3 and SAYP interact during development and have multiple common targets across the genome
Title: SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation.
DHR3 modulates dS6 kinase-dependent growth in Drosophila.
Title: The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila.
Mid-embryonic expression of DHR3 and betaFTZ-F1 is part of a 20-hydroxyecdysone (20E)-triggered transcriptional cascade, directing maximal expression of E74A and E75A during late embryogenesis.
Title: The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0778 (e-PCR)
- UniSTS:77389

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in compound eye photoreceptor fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of development, heterochronic	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hormone receptor 3

Names: CG33183-PA; CG33183-PC; CG33183-PD; CG33183-PF; CG33183-PH; CG33183-PI; Hr3-PA; Hr3-PC; Hr3-PD; Hr3-PF; Hr3-PH; Hr3-PI; complementation group D; hormone receptor-like 46; hormone receptor-like in 46

NP_001334718.1

non-AUG (ACG) translation initiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

10203995..10237348 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001347757.1 → NP_001334718.1 hormone receptor 3, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A384SX09
NM_001259307.3 → NP_001246236.1 hormone receptor 3, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246236.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P31396, Q9V5I0

UniProtKB/TrEMBL

A2VEG1, H1UUN3

Conserved Domains (2) summary

cd06968
Location:44 → 138

NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

cl11397
Location:236 → 478

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001103786.2 → NP_001097256.1 hormone receptor 3, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097256.1

Status: REVIEWED

UniProtKB/TrEMBL

A8DY91, Q8SXA4

Conserved Domains (2) summary

cd06968
Location:15 → 109

NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

cl11397
Location:205 → 447

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_176121.3 → NP_788301.1 hormone receptor 3, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788301.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z858

Related

FBpp0087454

Conserved Domains (2) summary

cd06968
Location:253 → 347

NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

cl11397
Location:443 → 685

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_176123.5 → NP_788303.1 hormone receptor 3, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788303.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P31396, Q9V5I0

UniProtKB/TrEMBL

A2VEG1, H1UUN3

Related

FBpp0087456

Conserved Domains (2) summary

cd06968
Location:44 → 138

NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

cl11397
Location:236 → 478

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001273925.2 → NP_001260854.1 hormone receptor 3, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260854.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEJ3, A2VEG1

Conserved Domains (2) summary

cd06968
Location:44 → 138

NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

cl11397
Location:236 → 478

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators