GluRIIB Glutamate receptor IIB [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GluRIIBprovided by FlyBase
Official Full Name: Glutamate receptor IIBprovided by FlyBase
Primary source: FLYBASE:FBgn0020429
Locus tag: Dmel_CG7234
See related: AllianceGenome:FB:FBgn0020429
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7234; DGluIIB; DGluR-IIB; dglurIIB; dGluRIIB; DGluRIIB; DmelGluRIIB; Dmel\CG7234; Glu-RIIB; glurIIB; GluRIIb
Summary: Enables glutamate-gated calcium ion channel activity. Involved in calcium ion transport; glutamatergic synaptic transmission; and neuromuscular synaptic transmission. Located in muscle cell postsynaptic specialization and postsynaptic membrane. Part of ionotropic glutamate receptor complex. Is expressed in embryonic/larval hypodermal muscle cell; embryonic/larval neuromuscular junction; larval somatic muscle cell; larval visceral muscle cell; and somatic muscle cell. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 25E6-25E6; 2-17 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5559342..5563502)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5559342..5563502)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Postsynaptic cAMP signalling regulates the antagonistic balance of Drosophila glutamate receptor subtypes.
Title: Postsynaptic cAMP signalling regulates the antagonistic balance of Drosophila glutamate receptor subtypes.
The postsynaptic density (PSD) houses glutamate receptors GluRIIA and GluRIIB, which have distinct transmission properties. In henji mutants, GluRIIA abundance is upregulated but that of GluRIIB is not.
Title: Dbo/Henji Modulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response.
Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction
Title: Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction.
examined glutamate receptor subunit mRNA expression and localization in embryonic/larval neuromuscular junctions; GluRIIA and GluRIIB mRNA abundance rises quickly approximately 20-fold, then falls within a few hours back to very low levels protein abundance gradually increases throughout development
Title: Drosophila glutamate receptor mRNA expression and mRNP particles.
We found that postsynaptic CaMKII regulates the localization of GluRIIA and GluRIIB, we hypothesize that postsynaptic CaMKII activity monitors the calcium influx through GluRIIA and regulate the amount of synaptic GluRIIA during larval stages
Title: Subunit-specific and homeostatic regulation of glutamate receptor localization by CaMKII in Drosophila neuromuscular junctions.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-gated calcium ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kainate selective glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ionotropic glutamate receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in muscle cell postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: glutamate receptor IIB

Names: CG7234-PI; GluRIIB-PI; glutamate receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5559342..5563502

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078761.3 → NP_523485.3 glutamate receptor IIB [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523485.3

Status: REVIEWED

UniProtKB/TrEMBL

O45028, Q9VMP3

Related

FBpp0088541, FBtr0089577

Conserved Domains (4) summary

cd06382
Location:26 → 393

PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors

cd13714
Location:422 → 795

PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily

pfam00060
Location:555 → 822

Lig_chan; Ligand-gated ion channel

pfam01094
Location:41 → 378

ANF_receptor; Receptor family ligand binding region