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    Jon25Bi Jonah 25Bi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33708, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jon25Biprovided by FlyBase
    Official Full Name
    Jonah 25Biprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020906
    Locus tag
    Dmel_CG8867
    See related
    AllianceGenome:FB:FBgn0020906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    25B; CG8867; Dmel\CG8867; Jon25; Jon25B; Jon25i; Ser4; SP137
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. Is expressed in larval digestive system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jon25Bi in Genome Data Viewer
    Location:
    25B4-25B4; 2-14 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4954279..4955144, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4954279..4955144, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Jonah 25Biii Neighboring gene Jonah 25Bii Neighboring gene Marcal1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43824

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and cloning of Ser4, a gene encoding a trypsin-like serine protease in Drosophila melanogaster. Ahrens JE, et al. Biochim Biophys Acta, 1998 Jan 21. PMID 9473638
    2. Drosophila C virus systemic infection leads to intestinal obstruction. Chtarbanova S, et al. J Virol, 2014 Dec. PMID 25253354, Free PMC Article
    3. The detection of Jonah gene transcripts in Drosophila by in situ hybridization. Akam ME, et al. EMBO J, 1985 Jan. PMID 2410252, Free PMC Article
    4. Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers. Hwang KK, et al. Proc Natl Acad Sci U S A, 2001 Sep 25. PMID 11562500, Free PMC Article
    5. Distinct functions of the laminin β LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila. Hollfelder D, et al. BMC Dev Biol, 2014 Jun 17. PMID 24935095, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jonah 25Bi
    Names
    CG8867-PB
    Jon25Bi-PB
    jonah 25B
    serine protease 4
    NP_001033873.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4954279..4955144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038784.2 → NP_001033873.1  jonah 25Bi [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZG4, Q9VMX7
      Conserved Domains (2) summary
      smart00020
      Location:36 → 257
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:37 → 260
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16101 O16101
    Q8SZG4 Q8SZG4
    Q9VMX7 Q9VMX7

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