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    NitFhit Nitrilase and fragile histidine triad fusion protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NitFhitprovided by FlyBase
    Official Full Name
    Nitrilase and fragile histidine triad fusion proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024945
    Locus tag
    Dmel_CG7067
    See related
    AllianceGenome:FB:FBgn0024945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7067; Dmel\CG7067; dNitFhit
    Summary
    Enables bis(5'-adenosyl)-triphosphatase activity. Involved in nucleobase-containing compound metabolic process. Predicted to be located in mitochondrion. Is expressed in adult head and organism. Orthologous to human NIT1 (nitrilase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NitFhit in Genome Data Viewer
    Location:
    61B2-61B2; 3-1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (203730..205309)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (203730..205309)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene rhinoceros Neighboring gene mrityu Neighboring gene Glycerol kinase 1 Neighboring gene uncharacterized protein Neighboring gene Pre-mRNA processing factor 4 kinase Neighboring gene thoc7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/β-catenin signalling pathway. Mittag S, et al. Cell Discov, 2016. PMID 27462437, Free PMC Article
    2. The Rosetta Stone Hypothesis-Based Interaction of the Tumor Suppressor Proteins Nit1 and Fhit. Mittag S, et al. Cells, 2023 Jan 17. PMID 36766695, Free PMC Article
    3. Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Pekarsky Y, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671749, Free PMC Article
    4. Chromosomal instability causes sensitivity to metabolic stress. Shaukat Z, et al. Oncogene, 2015 Jul 30. PMID 25347746
    5. Adaptation to Chronic Nutritional Stress Leads to Reduced Dependence on Microbiota in Drosophila melanogaster. Erkosar B, et al. mBio, 2017 Oct 24. PMID 29066546, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-triphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-adenosyl)-triphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deaminated glutathione amidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nucleobase-containing compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nitrilase and fragile histidine triad fusion protein
    Names
    CG7067-PA
    NitFhit-PA
    NitFlit
    NP_525122.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      203730..205309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080383.4 → NP_525122.1  nitrilase and fragile histidine triad fusion protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525122.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76464
      Related
      FBpp0072385
      Conserved Domains (2) summary
      cd07572
      Location:34 → 296
      nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)
      cd01275
      Location:317 → 436
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76464.1 O76464

    Gene LinkOut

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