upd2 unpaired 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: upd2provided by FlyBase
Official Full Name: unpaired 2provided by FlyBase
Primary source: FLYBASE:FBgn0030904
Locus tag: Dmel_CG5988
See related: AllianceGenome:FB:FBgn0030904
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg5988; CG5988; Dmel\CG5988; Unpaireds; upd; Upd; upd-2; Upd-2; Upd-like; Upd2; UPD2; Upd2/Leptin
Summary: Enables cytokine activity. Involved in several processes, including intestinal epithelial structure maintenance; lamellocyte differentiation; and paracrine signaling. Located in extracellular space. Is expressed in hindgut; organism; posterior spiracle primordium; and tracheal section. Used to study congenital leptin deficiency. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 17A3-17A3; 1-60 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18240654..18243284, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18134687..18137317, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insulin and Leptin/Upd2 Exert Opposing Influences on Synapse Number in Fat-Sensing Neurons.
Title: Insulin and Leptin/Upd2 Exert Opposing Influences on Synapse Number in Fat-Sensing Neurons.
Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila.
Title: Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila.
We further identify Upd2 as an activating ligand for JAK/STAT activity in the ASP. Together, these data constitute a considerable step forward in understanding the role of JAK/STAT signaling in ASPs and similar structures in mammalian models
Title: JAK/STAT signaling is involved in air sac primordium development of Drosophila melanogaster.
Study identified Unpaired 2 (Upd2), a protein with similarities to type I cytokines, as a secreted factor produced by the fat body in the fed state. When upd2 function is perturbed specifically in the FB, it results in a systemic reduction in growth and alters energy metabolism.
Title: Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion.
upd2 is expressed in a pattern essentially identical to that of upd and demonstrate that the proteins encoded by this region activate JAK/STAT pathway signalling
Title: Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand.
effect of a predicted gene related to unpaired, designated unpaired2, whose expression initiates during germ band extension.
Title: A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0501 (e-PCR)
- UniSTS:19978

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IEA Inferred from Electronic Annotation more info
involved_in intestinal epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in paracrine signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: unpaired 2

Names: CG5988-PC; Unpaired-2; Unpaired2; upd homolog; upd2-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

18240654..18243284 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001370039.1 → NP_001356882.1 unpaired 2 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4P1S8X3, D3PK89, Q9VWX2

Conserved Domains (1) summary

pfam15972
Location:144 → 360

Unpaired; Unpaired protein