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    galectin galectin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33162, updated on 27-Dec-2024

    Summary

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    Official Symbol
    galectinprovided by FlyBase
    Official Full Name
    galectinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031213
    Locus tag
    Dmel_CG11372
    See related
    AllianceGenome:FB:FBgn0031213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11372; Dmel\CG11372; Dmgal
    Summary
    Enables galactoside binding activity and glycosylation-dependent protein binding activity. Involved in synapse pruning and synaptic target recognition. Located in cytosol. Is expressed in several structures, including adult head; embryonic/larval hemocyte; ganglia; gut section; and muscle cell. Orthologous to several human genes including LGALS9B (galectin 9B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See galectin in Genome Data Viewer
    Location:
    21B1-21B1; 2-0.5 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (71757..76211)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (71757..76211)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45339 Neighboring gene long non-coding RNA:CR45340 Neighboring gene debra Neighboring gene antisense RNA:CR44987 Neighboring gene uncharacterized protein Neighboring gene net

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel Drosophila melanogaster galectin. Expression in developing immune, neural, and muscle tissues. Pace KE, et al. J Biol Chem, 2002 Apr 12. PMID 11809773
    2. Galectinomics: finding themes in complexity. Cooper DN. Biochim Biophys Acta, 2002 Sep 19. PMID 12223271
    3. Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning. Sung HH, et al. Nat Commun, 2024 Aug 27. PMID 39191750, Free PMC Article
    4. Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila. Lee TE, et al. Genetics, 2014 Oct. PMID 25081566, Free PMC Article
    5. TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins. McMahon AC, et al. Cell, 2016 Apr 21. PMID 27040499, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactoside binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosylation-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in synapse pruning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    galectin
    Names
    CG11372-PA
    CG11372-PB
    CG11372-PD
    CG11372-PE
    CG11372-PF
    galectin-PA
    galectin-PB
    galectin-PD
    galectin-PE
    galectin-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      71757..76211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258884.1 → NP_001245813.1  galectin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV96, M9NCX9
      Conserved Domains (2) summary
      cd00070
      Location:41 → 160
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
      pfam00337
      Location:237 → 377
      Gal-bind_lectin; Galactoside-binding lectin

    2. NM_134643.4 → NP_608487.1  galectin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV96, Q9VPI6
      Related
      FBpp0077760
      Conserved Domains (2) summary
      cd00070
      Location:143 → 262
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
      pfam00337
      Location:339 → 479
      Gal-bind_lectin; Galactoside-binding lectin

    3. NM_001272859.1 → NP_001259788.1  galectin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PUZ0
      Conserved Domains (2) summary
      pfam00337
      Location:108 → 248
      Gal-bind_lectin; Galactoside-binding lectin
      cl00071
      Location:2 → 31
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    4. NM_001169367.1 → NP_001162838.1  galectin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV96, E1JHP9
      Conserved Domains (2) summary
      cd00070
      Location:59 → 178
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
      pfam00337
      Location:255 → 395
      Gal-bind_lectin; Galactoside-binding lectin

    5. NM_001169366.2 → NP_001162837.1  galectin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162837.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV96, E1JHQ0
      Conserved Domains (2) summary
      cd00070
      Location:42 → 161
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
      pfam00337
      Location:238 → 378
      Gal-bind_lectin; Galactoside-binding lectin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0PUZ0 C0PUZ0
    E1JHP9 E1JHP9
    E1JHQ0 E1JHQ0
    M9NCX9 M9NCX9
    Q9VPI6 Q9VPI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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