U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    insv insensitive [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33441, updated on 9-Dec-2024

    Summary

    Official Symbol
    insvprovided by FlyBase
    Official Full Name
    insensitiveprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031434
    Locus tag
    Dmel_CG3227
    See related
    AllianceGenome:FB:FBgn0031434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE55538; CG3227; Dmel\CG3227; Insv
    Summary
    Enables chromatin insulator sequence binding activity; sequence-specific DNA binding activity; and transcription corepressor activity. Involved in negative regulation of DNA-templated transcription and negative regulation of Notch signaling pathway. Located in nucleus. Is expressed in several structures, including CNS glial cell; antennal anlage; antennal primordium; external sensory organ precursor cell; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See insv in Genome Data Viewer
    Location:
    23A1-23A1; 2-7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2575280..2576997, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2575280..2576997, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 309a2 Neighboring gene Radiation insensitive 1 Neighboring gene SWIM domain containing Srs2 interacting protein 1 Neighboring gene Early boundary activity 2 Neighboring gene NADH dehydrogenase (ubiquinone) B17.2 subunit

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding  
    enables chromatin insulator sequence binding PubMed 
    enables protein binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    enables transcription corepressor activity PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    insensitive
    Names
    CG3227-PA
    CG3227-PB
    insv-PA
    insv-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2575280..2576997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134846.3 → NP_608690.2  insensitive, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608690.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYK5, Q9VQD5
      Related
      FBpp0077426
      Conserved Domains (1) summary
      smart01025
      Location:278 → 356
      BEN; The BEN domain is found in diverse animal proteins
    2. NM_001298637.1 → NP_001285566.1  insensitive, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYK5, Q9VQD5
      Conserved Domains (1) summary
      smart01025
      Location:278 → 356
      BEN; The BEN domain is found in diverse animal proteins
    External link. Please review our privacy policy.